BACKGROUND: Identification and validation of biomarkers is increasingly important for the
integration of novel targeted agents in the treatment of cancer. The phosphatidylinositol 3 …

Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin
(mTOR) pathway regulates a broad spectrum of physiologic and pathologic processes. In …

Activation of the phosphoinositide 3 kinase (PI3K)/Akt/mammalian target of rapamycin
(mTOR) pathway is common in breast cancer. There is preclinical data to support inhibition …

Abstract The PI3K/Akt/mTOR pathway plays a role in various oncogenic processes in breast
cancer and key pathway aberrations have been identified which drive the different molecular …

The central role played by the class IA phosphatidylinositol-3-kinase (PI3K) signaling node
in human cancer is highlighted in the multiple mechanisms by which these signals become …

The phosphoinositide 3 kinase (PI3K)/Akt/mammalian (or mechanistic) target of rapamycin
(mTOR) pathway is a complicated intracellular pathway, which leads to cell growth and …

Aberrant activation of the PI3K/Akt/mTOR pathway is found in many types of cancer and thus
plays a major role in breast cancer cell proliferation and anti-cancer drug resistance. The …

Abstract The PI3K/Akt/mTOR (phosphatidylinositol 3 kinase/Akt/mammalian target of
rapamycin) signalling pathway is an established driver of oncogenic activity in human …

Simple Summary PI3K signaling pathway plays an essential role in many cellular processes
and is frequently altered in breast cancer, leading to increased tumor growth and reduced …

Abstract The phosphatidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin
(mTOR) signaling pathway is crucial to many aspects of cell growth and survival. The …