Ischaemia/reperfusion (I/R) injury of the heart represents a major health burden mainly
associated with acute coronary syndromes. While timely coronary reperfusion has become …

Despite major progress in interventional and medical treatments, myocardial infarction (MI)
and subsequent development of heart failure (HF) are still associated with high mortality …

Reductions in the blood supply produce considerable injury if the duration of ischemia is
prolonged. Paradoxically, restoration of perfusion to ischemic organs can exacerbate tissue …

Coronary arterial disease is the most common cardiovascular disease. Myocardial ischemia-
reperfusion injury caused by the initial interruption of organ blood flow and subsequent …

Reactive oxygen species (ROS) generation has been implicated in many pathologies
including ischemia/reperfusion (I/R) injury. This led to multiple studies on antioxidant …

Vascular pathologies pose a significant health problem because of their wide prevalence
and high impact on the rate of mortality. Blockade of blood flow in major blood vessels leads …

Acute myocardial infarction is the leading cause of cardiovascular‑related mortality and
chronic heart failure worldwide. As regards treatment, the reperfusion of ischemic tissue …

Mitochondria play a critical role in maintaining cellular function by ATP production. They are
also a source of reactive oxygen species (ROS) and proapoptotic factors. The role of …

Ischemia-reperfusion (IR) injury occurs when blood supply to an organ is disrupted—
ischemia—and then restored—reperfusion—leading to a burst of reactive oxygen species …

The heart is the most metabolically flexible organ with respect to the use of substrates
available in different states of energy metabolism. Cardiac mitochondria sense substrate …