Pathogenesis and treatment of human T-cell lymphotropic virus Type I-associated myelopathy

M Nagai, M Osame - Expert Review of Neurotherapeutics, 2002 - Taylor & Francis
Human T-cell lymphotropic virus Type I (HTLV-I)-associated myelopathy/tropical spastic
paraparesis (HAM/TSP) is a chronic progressive inflammatory neurological disease. It is …

Interferon‐β1a therapy in human T‐lymphotropic virus type I–associated neurologic disease

U Oh, Y Yamano, CA Mora, J Ohayon… - Annals of …, 2005 - Wiley Online Library
Human T‐lymphotropic virus type I (HTLV‐I)–associated myelopathy/tropical spastic
paraparesis (HAM/TSP) is an immune‐mediated inflammatory disorder of the central …

Advances in the treatment of human T-cell lymphotropic virus type-I associated myelopathy

B Mashkani, M Jalili Nik, SA Rezaee… - Expert Review of …, 2023 - Taylor & Francis
ABSTRACT Introduction Nearly 2–3% of those 10 to 20 million individuals infected with the
Human T-cell lymphotropic virus type-1 (HTLV-1); are predisposed to developing HTLV-1 …

Human T-cell lymphotropic virus type I and neurological diseases

M Nagai, M Osame - Journal of neurovirology, 2003 - Springer
Human T-cell lymphotropic virus type I (HTLV-I) infection is associated with a variety of
human diseases. In particular, there are two major diseases caused by HTLV-I infection …

Pathological mechanisms of human T-cell lymphotropic virus type I-associated myelopathy (HAM/TSP)

M Osame - Journal of neurovirology, 2002 - Taylor & Francis
The recent studies have greatly improved our understanding of the pathological
mechanisms of human T cell lymphotropic virus type I (HTLV-I)-associated …

Pathogenesis of human T‐lymphotropic virus type 1‐associated myelopathy/tropical spastic paraparesis

R Kubota - Clinical and Experimental Neuroimmunology, 2017 - Wiley Online Library
Human T‐lymphotropic virus type 1 (HTLV‐1) is a human retrovirus that preferentially infects
CD 4+ lymphocytes in vivo. The virus causes a hematological malignancy known as adult T …

Accumulation of human T-lymphotropic virus type I (HTLV-I)-infected cells in the cerebrospinal fluid during the exacerbation of HTLV-I-associated myelopathy

D Hayashi, R Kubota, N Takenouchi, T Nakamura… - Journal of …, 2008 - Springer
Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic
paraparesis (HAM/TSP) is a slowly progressive, inflammatory disease of the central nervous …

HTLV-I specific IFN-γ+ CD8+ lymphocytes correlate with the proviral load in peripheral blood of infected individuals

R Kubota, T Kawanishi, H Matsubara, A Manns… - Journal of …, 2000 - Elsevier
Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic
paraparesis (HAM/TSP) is an inflammatory neurological disease caused by HTLV-I infection …

Increased HTLV‐I proviral load and preferential expansion of HTLV‐I tax‐specific CD8+ T cells in cerebrospinal fluid from patients with HAM/TSP

M Nagai, Y Yamano, MB Brennan, CA Mora… - Annals of …, 2001 - Wiley Online Library
To date, high human T‐cell lymphotropic virus type I proviral load in patients with human T‐
cell lymphotropic virus type I‐associated myelopathy/tropical spastic paraparesis has been …

HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP): a chronic progressive neurologic disease associated with immunologically mediated damage …

MC Levin, S Jacobson - Journal of neurovirology, 1997 - Taylor & Francis
This review examines information on clinical, pathological and immunological events in the
slowly progressive neurologic disorder associated with the human T lymphotropic virus type …