Arrhythmic genotypes in familial dilated cardiomyopathy: implications for genetic testing and clinical management
Cardiac arrhythmias are frequently seen in patients with dilated cardiomyopathy (DCM) and
can precipitate heart failure and death. In patients with non-ischaemic DCM, evidence for the …
can precipitate heart failure and death. In patients with non-ischaemic DCM, evidence for the …
Genetic risk of arrhythmic phenotypes in patients with dilated cardiomyopathy
M Gigli, M Merlo, SL Graw, G Barbati… - Journal of the American …, 2019 - jacc.org
Background: Genotype-phenotype correlations in dilated cardiomyopathy (DCM) and, in
particular, the effects of gene variants on clinical outcomes remain poorly understood …
particular, the effects of gene variants on clinical outcomes remain poorly understood …
Emerging concepts in arrhythmogenic dilated cardiomyopathy
T Zegkos, T Panagiotidis, D Parcharidou… - Heart Failure …, 2021 - Springer
Dilated cardiomyopathy (DCM) represents one of the primary cardiomyopathies and may
lead to heart failure and sudden death. Until recently, ventricular arrhythmias were …
lead to heart failure and sudden death. Until recently, ventricular arrhythmias were …
Implications of genetic testing in dilated cardiomyopathy
JAJ Verdonschot, MR Hazebroek… - Circulation: Genomic …, 2020 - Am Heart Assoc
Background: Genetic analysis is a first-tier test in dilated cardiomyopathy (DCM). Electrical
phenotypes are common in genetic DCM, but their exact contribution to the clinical course …
phenotypes are common in genetic DCM, but their exact contribution to the clinical course …
Dilated cardiomyopathy: genetic determinants and mechanisms
EM McNally, L Mestroni - Circulation research, 2017 - Am Heart Assoc
Nonischemic dilated cardiomyopathy (DCM) often has a genetic pathogenesis. Because of
the large number of genes and alleles attributed to DCM, comprehensive genetic testing …
the large number of genes and alleles attributed to DCM, comprehensive genetic testing …
Arrhythmias as presentation of genetic cardiomyopathy
J Lukas Laws, MC Lancaster… - Circulation …, 2022 - Am Heart Assoc
There is increasing evidence regarding the prevalence of genetic cardiomyopathies, for
which arrhythmias may be the first presentation. Ventricular and atrial arrhythmias …
which arrhythmias may be the first presentation. Ventricular and atrial arrhythmias …
Arrhythmogenic phenotype in dilated cardiomyopathy: natural history and predictors of life‐threatening arrhythmias
A Spezzacatene, G Sinagra, M Merlo… - Journal of the …, 2015 - Am Heart Assoc
Background Patients with dilated cardiomyopathy (DCM) may present with ventricular
arrhythmias early in the disease course, unrelated to the severity of left ventricular …
arrhythmias early in the disease course, unrelated to the severity of left ventricular …
Genetic arrhythmias complicating patients with dilated cardiomyopathy
Z Li, P Chen, C Li, L Tan, J Xu, H Wang, Y Sun, Y Wang… - Heart Rhythm, 2020 - Elsevier
Background Sudden cardiac death due to malignant arrhythmias is a common cause of
death in dilated cardiomyopathy (DCM). Whether genetic variants increase the risk of …
death in dilated cardiomyopathy (DCM). Whether genetic variants increase the risk of …
Genotype-phenotype associations in dilated cardiomyopathy: meta-analysis on more than 8000 individuals
E Kayvanpour, F Sedaghat-Hamedani, A Amr… - Clinical Research in …, 2017 - Springer
Aims Routine genetic testing in Dilated Cardiomyopathy (DCM) has recently become reality
using Next-Generation Sequencing. Several studies have explored the relationship between …
using Next-Generation Sequencing. Several studies have explored the relationship between …
Genetics of Dilated Cardiomyopathy
R Eldemire, L Mestroni… - Annual review of medicine, 2024 - annualreviews.org
Dilated cardiomyopathy (DCM) is defined as dilation and/or reduced function of one or both
ventricles and remains a common disease worldwide. An estimated 40% of cases of familial …
ventricles and remains a common disease worldwide. An estimated 40% of cases of familial …
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