This paper will review some of the more recent developments in the study of opioid
receptors. It will be a general review with emphasis on the research performed in our own …

Two discoveries made in the first half of the 1970s sparked the enormous research activity
that has characterized the opiate field in recent years. The first was the biochemical …

The pharmacological concept of receptors, based upon the observation of rigid structure-
activity relationships, stereospecificity, and the observation of maximal pharmacological …

Major interest in the field of opiate research focuses on the issue of a heterogeneity of
receptors for opioids. Although the molecular structure of the opioid receptor macromolecule …

Of the peptide receptors examined, the opioid receptors are by far the most intensely studied
and best characterized systems in the CNS. They consist of at least three receptor types …

The initial proposal by Beckett and Casy (1954) that opiate drugs. might act through specific
receptors to produce analgesic effects was based on a comparison of the analgesic …

The in vivo study of opiates and opioid peptides is complicated by the multiple receptor
affinities of the drugs presently available (Wood et al., 1981b; Wood, 1982a; Wood, 1983a) …

This review begins with a brief summary of the discovery and earlier studies of opiate
receptors. The major portion of this chapter is devoted to the more recent advances in our …

In 1971, Goldstein et al. reported a set of criteria for the demonstration of specific opiate
receptors in neuronal membranes. Later Collier 11973) gave theoretical arguments in favour …

THE OPIATE receptor appears to be 'sculpted'for a normally occurring morphine-like
peptide, enkephalin, a neurotransmitter or neuromodulator of neuronal pathways in the …