Publisher Summary During sepsis and inflammation profound changes in physiological
function are induced by a variety of mediators, including endotoxin, various cytokines …

Peroxynitrite activates the cyclooxygenase activities of constitutive and inducible
prostaglandin endoperoxide synthases by serving as a substrate for the enzymes' …

N itric oxide (NO), first identified as an endothelium-derived relaxation factor, is now
recognized to regulate the functions of many mammalian cells and tissues. Nitric oxide is …

Nitric oxide (NO) is one of the critical components of the vasculature, regulating key
signaling pathways in health. In macrovessels, NO functions to suppress cell inflammation …

Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major
inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S …

Nitric oxide (NO) modulates the biological levels of arachidonate-derived cell signaling
molecules by either enhancing or suppressing the activity of prostaglandin H2 isoforms …

The role of nitric oxide (NO) in inflammation represents one of the most studied yet
controversial subjects in physiology. A number of reports have demonstrated that NO …

Since its initial discovery as an endogenously produced bioactive mediator, nitric oxide (•
NO) has been found to play a critical role in the cellular function of nearly all organ systems …

Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation.
To date, 3 distinct NOS isoforms have been identified: neuronal NOS (NOS1), inducible NOS …

The understanding of nitric oxide (NO) signaling has grown substantially since the
identification of endothelial derived relaxing factor (EDRF). NO has emerged as a ubiquitous …