Epidermal growth factor (EGF) plays an important role in tumorigenesis. The association
between the+ 61 A/G polymorphism of the EGF gene and colon cancer risk remains …

Epidermal Growth factor (EGF) could induce colorectal cancer (CRC) cell to develop
epithelial mesenchymal-transition and enhance their ability to invade and migrate. Several …

Background: Colorectal cancer was a complex disease with multiple causative factors
including genetic and environmental factors, as well as the interaction of the 2 factors …

Introduction. EGF/EGFR interactions are important mechanisms behind colorectal tumour
development and growth. Recently a single nucleotide polymorphism in the EGF gene has …

The epidermal growth factor (EGF) pathway stimulates proliferation and differentiation of
epidermal and epithelial tissues, and plays an important role in tumorigenesis. The …

Purpose: It has been shown that the R497K polymorphism of the epidermal growth factor
receptor (EGFR) has attenuated functions in ligand binding, tyrosine kinase activation, and …

Background: Colorectal cancer contributes heavily to cancer morbidity and mortality
worldwide. Numerous therapies are currently in use, including monoclonal antibodies …

Emerging evidences from preclinical and clinical studies have shown that epidermal growth
factor (EGF) has some effectiveness against endogenously arising carcinogenesis …

Colorectal cancer (CRC) is an important disorder that results from genetic and epigenetic
alterations in one colonic epithelial cell. Epidermal growth factor (EGF) is critical in the …

Aim The purpose of this study was to determine the relationship of rs4444903 (EGF+ 61A/G)
SNP genotype with colorectal cancer and tumor stage in an Iranian population. Background …