Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR) is a
key enzyme in the synthesis of isoprenoids in the malaria parasite, using a pathway that is …

This research has focused on the development of novel substrate mimics as potential DXR
inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR), an essential …

The methyl erythritol phosphate (MEP) pathway of isoprenoid biosynthesis is essential for
malaria parasites and also for several human pathogenic bacteria, thus representing an …

A three-dimensional model of the malarial drug target protein PfDXR was generated, and
validated using structure-checking programs and protein docking studies. Structural and …

The methylerythritol phosphate (MEP) pathway of Plasmodium falciparum (P. falciparum)
has become an attractive target for anti-malarial drug discovery. This study describes a …

Novel antimalarial drugs are urgently needed to treat severe malaria caused by Plasmodium
falciparum. Isoprenoid biosynthesis is a promising target pathway, since the biosynthetic …

1-Deoxy-d-xylulose-5-phosphate reductoisomerase (DXR) in the nonmevalonate isoprene
biosynthesis pathway is a target for developing antimalarial drugs. Fosmidomycin, a potent …

1-Deoxy-d-xylulose 5-phosphate reductoisomerase of Plasmodium falciparum (Pf IspC, Pf
Dxr), believed to be the rate-limiting enzyme of the nonmevalonate pathway of isoprenoid …

Abstract Blocking the 2‐C‐methyl‐d‐erythrithol‐4‐phosphate pathway for isoprenoid
biosynthesis offers new ways to inhibit the growth of Plasmodium spp. Fosmidomycin [(3‐(N …

The methylerythritol phosphate pathway to isoprenoids, an alternate biosynthetic route
present in many bacteria, algae, plants, and the malarial parasite Plasmodium falciparum …