As populations increase their life expectancy, age-related neurodegenerative disorders
such as Alzheimer's disease have become more common. I 2-Imidazoline receptors (I 2-IR) …

Brain aging and dementia are current problems that must be solved. The levels of
imidazoline 2 receptors (I 2-IRs) are increased in the brain in Alzheimer's disease (AD) and …

Imidazoline I2 receptors (I2-IR), widely distributed in the CNS and altered in patients that
suffer from neurodegenerative disorders, are orphans from a structural point of view, and …

Recent studies pointed out the modulation of imidazoline I 2 receptors (I 2-IR) by selective
ligands as a putative strategy to face neurodegenerative diseases. Foregoing the classical 2 …

Background and Purpose Activation of type 2 imidazoline receptors has been shown to
exhibit neuroprotective properties including anti‐apoptotic and anti‐inflammatory effects …

Recent findings unveil the pharmacological modulation of imidazoline I 2 receptors (I 2-IR)
as a novel strategy to face unmet medical neurodegenerative diseases. In this work, we …

Behavioural and psychological symptoms of dementia (BPSD), including fear-anxiety-and
depressive-like behaviour, are present in Alzheimer's disease (AD), together with memory …

The impact of neurodegenerative diseases (ND) is becoming unbearable for humankind
due to their vast prevalence and the lack of efficacious treatments. In this scenario, we …

Recent evidence suggests that I2-imidazoline ligands have neuroprotective properties in
animal models of neurodegeneration, such as Alzheimer's disease (AD). We recently …

Background and Purpose The development of effective therapeutic strategies against
Alzheimer's disease (AD) remains a challenge. I2 imidazoline receptor ligands have a …