Cytokines are very potent pro-inflammatory agents. Several cytokines are present in
abnormal quantities in asthmatic airway tissues. In vitro and in vivo experiments …

Although research in asthma has concentrated on complex proinflammatory mechanisms, it
is likely that defective expression of cytokines that inhibit allergic inflammation, such as …

Interleukin‐10 (IL‐10) is a cytokine derived from CD 4+ T‐helper type 2 (TH2) cells identified
as a suppressor of cytokines from T‐helper type 1 (TH1) cells. Interleukin‐12 (IL‐12) is …

ABSTRACT Interleukin (IL)-9 is a pleiotropic Th2 type cytokine which has been shown to
play an important role in the pathogenesis of bronchial asthma. This review will concentrate …

Asthma is a common, chronic inflammatory condition of the airways that leads to airway
hyperresponsiveness, reversible narrowing of the airways, and airway wall remodeling …

Abstract T helper (Th) 2 cytokines, particularly interleukin 4 (IL-4), IL-5 and IL-13, might be
important in the development of allergic asthma. Humanized monoclonal antibodies …

T helper (Th) type 2 cytokines, particularly interleukin (IL)-4, IL-5, and IL-13, may be
important in the development of allergic asthma. Humanized monoclonal antibodies …

Interleukin-4 mediates important proinflammatory functions in asthma, including induction of
the IgE isotype switch, expression of VCAM-1 on endothelium, mucin production, 15 …

Interleukin-5 is produced by a number of cell types, and is responsible for the maturation
and release of eosinophils in the bone marrow. In humans, interleukin-5 is a very selective …

Asthma is a complex heritable inflammatory disorder of the airways in which the
development of clinical disease depends on environmental exposure. It has been well …