Metabolic reprogramming is implicated in macrophage activation, but the underlying
mechanisms are poorly understood. Here, we demonstrate that the NOTCH1 pathway …

Activation of macrophages by inflammatory stimuli induces reprogramming of mitochondrial
metabolism to support the production of pro-inflammatory cytokines and nitric oxide …

Notch signaling plays an emerging role in the regulation of immune cell development and
function during inflammatory response. Activation of the ras homolog gene family member …

Profound metabolic changes are characteristic of macrophages during classical activation
and have been implicated in this phenotype. Here we demonstrate that nitric oxide (NO) …

Background & Aims Hepatic immune system disorder plays a critical role in the
pathogenesis of acute liver injury. The intrinsic signaling mechanisms responsible for …

Activated macrophages undergo metabolic reprogramming, which drives their pro-
inflammatory phenotype, but the mechanistic basis for this remains obscure. Here, we …

The liver is not only the main metabolic site of exogenous compounds and drugs, but also
an important immune organ in the human body. When a large number of nonself substances …

Mitochondria are signaling hubs in cellular physiology that play a role in inflammatory
diseases. We found that partial inhibition of the mitochondrial ATP synthase in the intestine …

Macrophages are found in most tissues of the body, where they have tissue-and context-
dependent roles in maintaining homeostasis as well as coordinating adaptive responses to …

The Notch signaling pathway plays major roles in organ development across animal
species. In the mammalian liver, Notch has been found critical in development, regeneration …