Laboratory diagnostics and therapy in thrombosis and hemostasis: from bedside to bench to bedside

G Lippi, EJ Favaloro, M Franchini - Seminars in thrombosis and …, 2009 - thieme-connect.com
Thrombosis and Hemostasis for 2009. The theme for this issue,''Laboratory Diagnostics and
Therapy in Thrombosis and Hemostasis: From Bedside to Bench to Bedside,''arose from two …

Next-Generation Sequencing in the Clinical Laboratory

DL Duncan, NM Patel - Diagnostic Molecular Pathology, 2017 - Elsevier
Next-generation (or massively parallel) sequencing has rapidly supplanted traditional
Sanger sequencing as the preferred methodology for acquiring clinical sequence data …

Genome-scale sequencing in clinical care: establishing molecular diagnoses and measuring value

JS Berg - Jama, 2014 - jamanetwork.com
The arrival of genomic medicine was presaged by the publication of the draft human
genome sequence in 2001. 1, 2 Now, the application of genome-scale sequencing is being …

Review of applications of high-throughput sequencing in personalized medicine: barriers and facilitators of future progress in research and clinical application

G Lightbody, V Haberland, F Browne… - Briefings in …, 2019 - academic.oup.com
There has been an exponential growth in the performance and output of sequencing
technologies (omics data) with full genome sequencing now producing gigabases of reads …

Building evidence and measuring clinical outcomes for genomic medicine

JF Peterson, DM Roden, LA Orlando, AH Ramirez… - The Lancet, 2019 - thelancet.com
Human genomic sequencing has potential diagnostic, prognostic, and therapeutic value
across a wide breadth of clinical disciplines. One barrier to widespread adoption is the …

Explanatory chapter: next generation sequencing

S Yegnasubramanian - Methods in enzymology, 2013 - Elsevier
Technological breakthroughs in sequencing technologies have driven the advancement of
molecular biology and molecular genetics research. The advent of high-throughput Sanger …

Genomic sequencing in clinical trials

KK Mestan, L Ilkhanoff, S Mouli, S Lin - Journal of translational medicine, 2011 - Springer
Human genome sequencing is the process by which the exact order of nucleic acid base
pairs in the 24 human chromosomes is determined. Since the completion of the Human …

Introduction to the analysis of next generation sequencing data and its application to venous thromboembolism

MLR Cunha, JCM Meijers… - Thrombosis and …, 2015 - thieme-connect.com
Despite knowledge of various inherited risk factors associated with venous
thromboembolism (VTE), no definite cause can be found in about 50% of patients. The …

Personalized medicine in thrombosis: back to the future

S Nagalla, PF Bray - Blood, The Journal of the American …, 2016 - ashpublications.org
Most physicians believe they practiced personalized medicine prior to the genomics era that
followed the sequencing of the human genome. The focus of personalized medicine has …

Next Generation Sequencing strategies in venous thromboembolism: in whom and for what purpose?

DA Trégouët, M Pierre-Emmanuel - Journal of Thrombosis and …, 2024 - Elsevier
This invited review follows the oral presentation" To Sequence or Not to Sequence, That Is
Not the Question; But" When, Who, Which and What For?" Is “given during the State Of the …