Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins

J Rieger, W Wick, M Weller - Glia, 2003 - Wiley Online Library
Semaphorins comprise a family of molecules implicated in the guiding of growing axons and
neuronal progenitor cells. Further, semaphorins have been suggested to play a role in …

Semaphorin signaling in cancer cells and in cells of the tumor microenvironment–two sides of a coin

L Capparuccia, L Tamagnone - Journal of cell science, 2009 - journals.biologists.com
Semaphorins are a large family of secreted and membrane-bound molecules that were
initially implicated in the development of the nervous system and in axon guidance. More …

The emerging role of class-3 semaphorins and their neuropilin receptors in oncology

P Nasarre, RM Gemmill, HA Drabkin - OncoTargets and therapy, 2014 - Taylor & Francis
The semaphorins, discovered over 20 years ago, are a large family of secreted or
transmembrane and glycophosphatidylinositol-anchored proteins initially identified as axon …

[PDF][PDF] Semaphorins in cancer

G Neufeld, N Shraga-Heled, T Lange… - Front Biosci, 2005 - researchgate.net
The semaphorins are the products of a large family of genes currently containing more than
30 members. These genes are divided into eight classes of which classes 1, 2 and 8 contain …

The semaphorins: versatile regulators of tumour progression and tumour angiogenesis

G Neufeld, O Kessler - Nature Reviews Cancer, 2008 - nature.com
The semaphorins and their receptors, the neuropilins and the plexins, were originally
characterized as constituents of the complex regulatory system responsible for the guidance …

Semaphorins and their receptors in lung cancer

VA Potiron, J Roche, HA Drabkin - Cancer letters, 2009 - Elsevier
Semaphorins are a large family of secreted, transmembrane and GPI-linked proteins initially
characterized in the development of the nervous system and axonal guidance. Semaphorins …

Neuropilins as Semaphorin receptors: in vivo functions in neuronal cell migration and axon guidance

A Bagri, M Tessier-Lavigne - … : From Nervous System to Vascular and …, 2002 - Springer
After the initial discovery of neuropilin-1 as an epitope on axons recognized by a
monoclonal antibody, neuropilins were rediscovered in the search for receptors mediating …

The role of the semaphorins in cancer

G Neufeld, Y Mumblat, T Smolkin… - Cell Adhesion & …, 2016 - Taylor & Francis
The semaphorins were initially characterized as axon guidance factors, but have
subsequently been implicated also in the regulation of immune responses, angiogenesis …

[HTML][HTML] Class-3 semaphorins and their receptors: potent multifunctional modulators of tumor progression

S Toledano, I Nir-Zvi, R Engelman, O Kessler… - International journal of …, 2019 - mdpi.com
Semaphorins are the products of a large gene family containing 28 genes of which 21 are
found in vertebrates. Class-3 semaphorins constitute a subfamily of seven vertebrate …

Role of class 3 semaphorins and their receptors in tumor growth and angiogenesis

P Gaur, DR Bielenberg, S Samuel, D Bose, Y Zhou… - Clinical cancer …, 2009 - AACR
Abstract Class 3 semaphorins (SEMA3) were first identified as glycoproteins that negatively
mediate neuronal guidance by binding to neuropilin and repelling neurons away from the …