In an attempt to predict the likelihood of successfully treating sickle cell disease by
increasing haemoglobin S (Hb S) oxygen affinity, two liganded derivatives of Hb S have …

1. The formation of polymerized haemoglobin S in sickle cells is critically dependent on the
concentration of deoxygenated haemoglobin so that compounds which increase the oxygen …

We have demonstrated that the extent of intracellular polymerization of deoxyhemoglobin S
can be predicted from knowledge of intracellular hemoglobin concentration, composition …

The effect of urea on the oxygen affinity of sickle cells and normal cells was studied up to a
concentration of about 1.0 M. Besides the increase in oxygen affinity found in both normal …

Sickle-cell disease arises from the homozygous inheritance of genes which synthesize Hb-S
rather than Hb-A. Its prevention and treatment are of great importance both because of its …

The relationship between the irreversibly sickled cell (ISC) count and other haematological
parameters has been investigated. Positive correlations occurred with the MCH, MCHC, and …

The term sickle-cell disease includes any state where the proportion of haemoglobin S is
greater than 50%(eg sickle-cell anaemia, sickle-cell haemoglobin C disease and sickle-cell …

To determine the extent to which the broad distribution in intracellular hemoglobin
concentrations found in sickle erythrocytes affects the extent of intracellular polymerization of …

We have used 13C/1H magnetic double-resonance spectroscopy to measure the amount of
sickle hemoglobin polymer within sickle erythrocytes as a function of oxygen saturation. We …

Solution and cell studies were performed to ascertain why individuals with hemoglobin (Hb)
SC have disease whereas those with Hb AS do not. The polymerization of deoxygenated …