Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …

▪ Abstract The insulin resistance syndrome refers to a constellation of findings, including
glucose intolerance, obesity, dyslipidemia, and hypertension, that promote the development …

Insulin resistance is a complex metabolic disorder that defies explanation by a single
etiological pathway. Accumulation of ectopic lipid metabolites, activation of the unfolded …

Insulin resistance is the pivotal pathogenic component of many metabolic diseases,
including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of …

Insulin signaling at the target tissue results in a large array of biological outcomes. These
events are essential for normal growth and development and for normal homeostasis of …

The centenary of insulin discovery represents an important opportunity to transform diabetes
from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key …

Insulin resistance is one of the earliest defects in the pathogenesis of type 2 diabetes. Over
the past 50 years, elucidation of the insulin signalling network has provided important …

Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin.
Insulin signaling is therefore critical for these tissues. However, decrease in insulin …

The past 20 years have witnessed a remarkable increase in our knowledge of the cellular
and molecular mechanisms that underlie the diverse actions of insulin, the central hormone …

Following the discovery of insulin by Banting and Best in 1922, it was widely assumed that
human diabetes was due exclusively to a deficiency in the secretion of the hormone …