Probing lung microstructure with hyperpolarized 3He gradient echo MRI

AL Sukstanskii, JD Quirk, DA Yablonskiy - NMR in Biomedicine, 2014 - Wiley Online Library
In this paper we demonstrate that gradient echo MRI with hyperpolarized 3He gas can be
used for simultaneously extracting in vivo information about lung ventilation properties …

Imaging lung microstructure in mice with hyperpolarized 3He diffusion MRI

W Wang, NM Nguyen, DA Yablonskiy… - Magnetic resonance …, 2011 - Wiley Online Library
Quantitative measurement of lung microstructure is of great significance in assessment of
pulmonary disease, particularly in the earliest stages. The technique for MRI‐based 3He …

In vivo lung morphometry with accelerated hyperpolarized 3He diffusion MRI: A preliminary study

YV Chang, JD Quirk… - Magnetic resonance in …, 2015 - Wiley Online Library
Purpose Parallel imaging can be used to reduce imaging time and to increase the spatial
coverage in hyperpolarized gas magnetic resonance imaging of the lung. In this proof‐of …

[HTML][HTML] Quantification of lung microstructure with hyperpolarized 3He diffusion MRI

DA Yablonskiy, AL Sukstanskii… - Journal of applied …, 2009 - journals.physiology.org
The structure and integrity of pulmonary acinar airways and their changes in different
diseases are of great importance and interest to a broad range of physiologists and …

Assessment of in vitro vs. in vivo lung structure using hyperpolarized helium-3 diffusion magnetic resonance imaging

JF Mata, TA Altes, K Ruppert, KD Hagspiel… - Magnetic resonance …, 2009 - Elsevier
The purpose of this study was to assess the properties of a model system for hyperpolarized
He-3 (HHe) diffusion MR imaging created from the lungs of New Zealand white rabbits by …

MR tagging of human lungs using hyperpolarized 3He gas

JR Owers‐Bradley, MS Fichele… - Journal of Magnetic …, 2003 - Wiley Online Library
Purpose To evaluate the use of spin‐tagging in conjunction with hyperpolarized gas
imaging for monitoring lung ventilation and gas diffusion. Methods and Materials Images …

Dynamic echo planar MR imaging of lung ventilation with hyperpolarized 3He in normal subjects and patients with severe emphysema

DS Gierada, B Saam, D Yablonskiy… - NMR in Biomedicine …, 2000 - Wiley Online Library
We applied the rapid imaging capability of echo planar MR pulse sequences and
hyperpolarized 3He ventilation imaging to observe the dynamic distribution of gas in the …

q‐space analysis of lung morphometry in vivo with hyperpolarized 3He spectroscopy

DD Shanbhag, TA Altes, GW Miller… - Journal of Magnetic …, 2006 - Wiley Online Library
Purpose To examine the utility of a 3He spectroscopic q‐space technique for detecting
changes in lung morphometry in vivo. Materials and Methods A diffusion‐weighted …

Regional anisotropy of airspace orientation in the lung as assessed with hyperpolarized helium‐3 diffusion MRI

P Komlosi, TA Altes, K Qing, KE Mooney… - Journal of Magnetic …, 2015 - Wiley Online Library
Purpose To evaluate regional anisotropy of lung‐airspace orientation by assessing the
dependence of helium‐3 (3He) apparent diffusion coefficient (ADC) values on the direction …

Quantitative assessment of lung microstructure in healthy mice using an MR-based 3He lung morphometry technique

E Osmanagic, AL Sukstanskii… - Journal of Applied …, 2010 - journals.physiology.org
The recently developed technique of lung morphometry using hyperpolarized 3He diffusion
magnetic resonance (MR)(Yablonskiy DA, Sukstanskii AL, Woods JC, Gierada DS, Quirk JD …