Self-organization of the in vitro attached human embryo
Implantation of the blastocyst is a developmental milestone in mammalian embryonic
development. At this time, a coordinated program of lineage diversification, cell-fate …
development. At this time, a coordinated program of lineage diversification, cell-fate …
Molecular recording of mammalian embryogenesis
MM Chan, ZD Smith, S Grosswendt, H Kretzmer… - Nature, 2019 - nature.com
Ontogeny describes the emergence of complex multicellular organisms from single
totipotent cells. This field is particularly challenging in mammals, owing to the indeterminate …
totipotent cells. This field is particularly challenging in mammals, owing to the indeterminate …
Single-cell genomics to guide human stem cell and tissue engineering
JG Camp, D Wollny, B Treutlein - Nature methods, 2018 - nature.com
To understand human development and disease, as well as to regenerate damaged tissues,
scientists are working to engineer certain cell types in vitro and to create 3D …
scientists are working to engineer certain cell types in vitro and to create 3D …
[HTML][HTML] LifeMap Discovery™: the embryonic development, stem cells, and regenerative medicine research portal
LifeMap Discovery™ provides investigators with an integrated database of embryonic
development, stem cell biology and regenerative medicine. The hand-curated reconstruction …
development, stem cell biology and regenerative medicine. The hand-curated reconstruction …
Single-cell multi-omics sequencing of human early embryos
DNA methylation, chromatin states and their interrelationships represent critical epigenetic
information, but these are largely unknown in human early embryos. Here, we apply single …
information, but these are largely unknown in human early embryos. Here, we apply single …
Systems-level dynamic analyses of fate change in murine embryonic stem cells
Molecular regulation of embryonic stem cell (ESC) fate involves a coordinated interaction
between epigenetic,,,, transcriptional,,,,, and translational, mechanisms. It is unclear how …
between epigenetic,,,, transcriptional,,,,, and translational, mechanisms. It is unclear how …
[HTML][HTML] Embryo-scale reverse genetics at single-cell resolution
The maturation of single-cell transcriptomic technologies has facilitated the generation of
comprehensive cellular atlases from whole embryos,,–. A majority of these data, however …
comprehensive cellular atlases from whole embryos,,–. A majority of these data, however …
[HTML][HTML] Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia
The human cortex comprises diverse cell types that emerge from an initially uniform
neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To …
neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To …
Organoid single-cell genomic atlas uncovers human-specific features of brain development
The human brain has undergone substantial change since humans diverged from
chimpanzees and the other great apes,. However, the genetic and developmental programs …
chimpanzees and the other great apes,. However, the genetic and developmental programs …
A reversible haploid mouse embryonic stem cell biobank resource for functional genomics
The ability to directly uncover the contributions of genes to a given phenotype is
fundamental for biology research. However, ostensibly homogeneous cell populations …
fundamental for biology research. However, ostensibly homogeneous cell populations …