Background Obesity and insulin resistance/diabetes are important risk factors for
cardiovascular diseases and demand safe and efficacious therapeutics. Objective To assess …

Ethnopharmacological relevance Agriophyllum squarrosum (L.) Moq. is a traditional Mongol
medicine generally used to treat diabetes. Objective To investigate the protective effects and …

Objective—We investigated whether the dual PPARα/γ agonist tesaglitazar has anti-
atherogenic effects in ApoE* 3Leiden mice with reduced insulin sensitivity. Methods and …

Increased circulating free fatty acid (FFA) concentrations have been demonstrated to
potentially link obesity, insulin resistance and cardiovascular diseases. Astragaloside IV (AS …

Excess cardiac triglyceride accumulation in diabetes and obesity induces lipotoxicity, which
predisposes the myocytes to death. On the other hand, increased cardiac fatty acid (FA) …

AIM: To determine the effects of the peroxisome proliferator-activated receptor (PPAR) α/γ
agonist tesaglitazar on serum levels of apolipoprotein (apo) AI, apoB, and apoCIII in non …

Prevailing knowledge links chronic low-grade inflammation in the adipose tissue to obesity
and its associated metabolic complications. In this study, we evaluated immunometabolic …

Several herbal medicines improve hyperlipidemia, diabetes and cardiovascular diseases.
However, the molecular mechanism underlying this improvement has not yet been clarified …

Background Previous research demonstrated that the crude saponins of Platycodi radix
improve glucose metabolism by enhancing insulin sensitivity in type 2 diabetic animals; …

Background Berberine is a phytochemical derived from various plants and is found to be
beneficial in the treatment of cardiovascular, hepatic, metabolic, renal and infectious …