Background Klotho is a transmembrane protein acting as a co-receptor for FGF-23 and thus
exerts clinical actions on mineral metabolism. The association of secreted Klotho with …

Background Dialysis patients suffer from a high burden of cardiovascular disease (CVD).
Partly this is due to progressive deterioration of calcium-phosphate homeostasis. Previous …

Background Klotho, a protein linked to aging, has emerged as a pivotal player in mineral
bone metabolism and might explain the relationship between chronic kidney disease (CKD) …

Background: Soluble Klotho plays an important role in cardiovascular disease and death in
chronic kidney disease (CKD). We assessed the relationship between serum soluble Klotho …

Background: Experimental studies indicate that Klotho deficiency is a pathogenic factor for
CKD-related complications, including cardiovascular disease (CVD). However, the …

Chronic kidney disease (CKD) has been associated with a higher risk of cardiovascular
disease (CVD). CKD patients present a decrease in the levels of the protein Klotho that …

Background Klotho was originally identified in a mutant mouse strain unable to express the
gene that consequently showed shortened life spans. In humans, low serum Klotho levels …

Background Klotho gene was identified as an aging suppressor. In animals, klotho
overexpression extends life span, and defective klotho results in rapid aging and early …

Introduction: This study aimed to investigate the relationship between circulating soluble
Klotho concentration and all-cause mortality in individuals with chronic kidney disease …

Klotho is a membrane-bound protein acting as an obligatory coreceptor for fibroblast growth
factor 23 (FGF23) in the kidney and parathyroid glands. The extracellular portion of its …