Functional studies of the interleukin 2 receptor (IL-2R) of two (ED515-D and Kit225) IL-2-
dependent and three (ED515-I, 3T3-alpha beta 11, and Hut102) IL-2-independent cell lines …

We previously established several mouse hybridoma cell lines producing monoclonal
antibodies against the human interleukin 2 (IL 2) receptor molecule. As they bind to both …

Interleukin 2 (IL-2)-mediated signaling through its high-affinity receptor involves a complex
interrelationship between IL-2 and two IL-2-binding chains, IL-2R alpha and beta chains …

The interleukin 2 (IL-2) receptor (IL-2R) is a multisubunit receptor that includes three major
IL-2 binding subunits, the IL-2R alpha, beta, and gamma chains. We have detected and …

Previous studies have shown that binding of interleukin 1 (IL-1) to its receptor and
intracellular processing of the IL-1/IL-1 receptor complex appear to be different in B-and T …

Abstract Human interleukin 2 (IL-2) receptor cDNA derived from HUT 102B2 cells was stably
expressed in murine L cells. These L cell transfectants (a) displayed surface receptors of the …

Human interleukin 1 beta (IL-1 beta) exerts its diverse biological effects by binding to
specific receptors on target cells. Two types of IL-1 receptor (IL-1R) have been identified: the …

Interleukin 2 (IL-2) receptors expressed on the surface of activated T cells and natural killer
(NK) cells exhibit a variety of affinity states depending on their subunit composition. Low …

The human high-affinity receptor for interleukin 2 (IL-2) has been proposed as being a
membrane complex composed of at least two distinct polypeptide chains: p55 (alpha chain) …

High-affinity IL-2-R binding results from an exceptional type of cooperative interaction
between two IL-2-binding proteins termed alpha and beta. When expressed together on the …