Poly (ADP-ribose) polymerase (PARP, EC 2.4. 2.30), an abundant nuclear protein activated
by DNA nicks, mediates cell death in vitro by nicotinamide adenine dinucleotide (NAD) …

Background and Purpose—The nuclear enzyme poly (ADP-ribose) polymerase (PARP) may
play a role in DNA repair. However, in cerebral ischemia, excessive PARP activation may …

Poly (ADP-ribose) polymerases (PARPs) are enzymes that are able to catalyze the transfer
of ADP-ribose units from NAD to substrate proteins and are particularly abundant in cell …

Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme, activated by DNA strand
breaks to participate in DNA repair. Overactivation of PARP by cellular insults depletes its …

Focal cerebral ischemia activates the nuclear protein poly (ADP-ribose) polymerase (PARP)
by single DNA strand breaks which leads to energy depletion and cell necrosis. Deletion or …

Poly (ADP‐ribose) synthase (PARS), an abundant nuclear protein, has been described as
an important candidate for mediation of neurotoxicity by nitric oxide. However, in cerebral …

Excessive activation of the nuclear enzyme, poly (ADP-ribose) polymerase-1 (PARP-1)
plays a prominent role in various of models of cellular injury. Here, we identify poly (ADP …

Poly (ADP-ribose) polymerase (PARP) is thought to play a physiological role in maintaining
genomic integrity and in the repair of DNA strand breaks. However, the activation of PARP …

Nitric oxide from neuronal cells plays detrimental roles in glutamate neurotoxicity and in
focal brain ischemia. Nitric oxide directly damages DNA, and breaks in the DNA strands …

Nitric oxide (NO) and peroxynitrite, formed from NO and superoxide anion, have been
implicated as mediators of neuronal damage following focal ischemia, but their molecular …