Background The purpose of this study was to compare the effects of isoflurane on
membrane and intracellular mechanisms that regulate vascular smooth muscle (VSM) …

Background A primary source of calcium (Ca2+) necessary for excitation contraction in
vascular smooth muscle (VSM) is influx via voltage-dependent Ca2+ channels. Thus, force …

Background Administration of general anesthetics to patients with chronic hypertension
often causes hemodynamic instability that has been attributed in part to a poorly understood …

Introduction This study was designed to compare the inhibitory effect of inhaled volatile
anesthetic agents on in situ sympathetic neural versus nonneural regulation of vascular …

We measured the effects of inhaled isoflurane on hypoxemia-induced changes in the
diameter of small mesenteric (capacitance-regulating) veins, sympathetic efferent neural …

Background It is believed that isoflurane decreases blood pressure predominantly by
decreasing systemic vascular resistance with modest myocardial depression. Nevertheless …

Isoflurane is a potent systemic vasodilator. Because isoflurane vasodilation is clinically
significant, we sought to explore whether decreases in systemic vascular resistance caused …

The contributions of the vasodilators nitric oxide (NO) and endothelium-derived
hyperpolarizing factor (EDHF) were investigated in the rat cremaster muscle microcirculation …

Background Vascular endothelium plays an important role in the regulation of vascular tone.
Volatile anesthetics have been shown to attenuate endothelium-mediated relaxation in …

Purpose Arginine vasopressin (AVP) is a potent vasoconstrictor that is sometimes used for
the treatment of refractory vasodilatory shock. AVP constricts vascular smooth muscle by …