NSAIDs (non-steroidal anti-inflammatory drugs) prevent colon and other cancers. The fact
that NSAIDs inhibit the eicosanoid pathway prompted mechanistic drug-developmental work …

The seminal epidemiological observation that nonsteroidal anti-inflammatory drugs
(NSAIDs) prevent colon and possibly other cancers has spurred novel approaches to cancer …

Chemoprevention represents a highly promising approach for the control of cancer. That
nonsteroidal anti-inflammatory drugs (NSAIDs) prevent colon and other cancers has led to …

Multiple lines of evidence suggest that aberrant induction and upregulation of the
prostaglandin cascade play a significant role in colon and mammary carcinogenesis, and …

Cyclooxygenase-2 (COX-2), the inducible cyclooxygenase isozyme involved in the
conversion of arachidonic acid (AA) to biologically active prostanoids, has become the …

Cyclooxygenase (COX)-2, an inducible enzyme involved in prostaglandin biosynthesis, has
attracted considerable attention recently, due to its role in human cancer biology. Several …

COX-2 is upregulated at an early stage in colorectal carcinogenesis and generates
prostaglandins, which promote cancer cell proliferation, impair apoptosis and enhance …

The cyclooxygenase-2 (COX-2) enzyme has a fundamental role in the carcinogenesis of
colorectal cancer. The anticarcinogenic mechanisms of NSAIDs are not completely …

Epidemiological and experimental studies have demonstrated the effect of non-steroidal anti-
inflammatory drugs (NSAIDs) in the prevention of human cancers. NSAIDs block …

Epidemiological and clinical studies suggest that non-steroidal anti-inflammatory drugs
(NSAIDs), including cyclooxygenase (COX)-2 selective inhibitors, reduce the risk of …