Abstract Cyclooxygenase2 (COX-2), an inducible prostaglandin G/H synthase, is
overexpressed in several human cancers. Here, the potential utility of selective COX-2 …

Chemoprevention refers to the use of natural or synthetic agents to reverse, suppress, or
prevent progression or recurrence of cancer. Colorectal cancers result from complex …

NSAIDs (4). However, it is clear from all of the studies COX-2 selective NSAIDs have an
improved gastrointestinal published to date that use of NSAIDs alone does not eradicate …

Evidence derived from several lines of investigation suggest that prostaglandins,
metabolites of arachidonic acid, play an important role in colon cancer development …

Colorectal cancer is a leading cause of cancer death throughout the world. The high
prevalence and mortality associated with colon cancer make effective prevention and …

An expanding body of evidence indicates that downregulation of the cy-clooxygenases (Cox-
1 and Cox-2) will be an important strategy for preventing cancer because cyclooxygenases …

Cyclooxygenase (COX), the key regulatory enzyme for prostaglandin synthesis, is
transcribed from two distinct genes. COX-1 is expressed constitutively in most tissues …

Cyclooxygenase (COX)-2 is a major player in inflammation and cancer. It is one of two COXs
that convert arachidonic acid to a common intermediate in the production of prostaglandins …

NSAIDs are powerful chemopreventive agents for colon cancer, but their mechanism of
action remains unknown. Their best recognized pharmacological property is inhibition of the …

Chemoprevention of colorectal cancer is a promising science that has particular importance
due to the limited success of current treatments for most advanced common malignancies …