Acute inflammation or resolved inflammation is an adaptive host defense mechanism and is
self-limiting, which returns the body to a state of homeostasis. However, unresolved …

The epidemiologic evidence and rodent studies suggest strongly that nonselective inhibitors
of cyclooxygenase (COX) enzymes such as aspirin, inhibiting both COX‐1 and COX‐2 …

Cyclooxygenase (COX) inhibitors are being developed as potential agents for the
prevention and treatment of cancer after a century of widespread use for inflammation, fever …

Clinical and preclinical studies provide strong evidence that nonsteroidal anti-inflammatory
drugs (NSAIDs) can prevent numerous types of cancers, especially colorectal cancer …

The rate-limiting step in arachidonate metabolism is mediated by enzymes known as
cyclooxygenases (COXs). These enzymes catalyze the biosynthesis of prostaglandin H 2 …

Non‐steroidal anti‐inflammatory drugs (NSAIDs), both cyclooxygenase‐2 (COX‐2) selective
and nonselective inhibitors, are amongst the most popular medications worldwide. Whilst …

Epidemiological observations and laboratory research have suggested that nonsteroidal
anti-inflammatory drugs (NSAIDs) reduce the risk of colon cancer and that the inhibition of …

Background and aims. Discovery of an isoform of Cyclo-oxygenase (COX) 1, the inducible
COX-2, has made it possible to avoid some side effects of non-specific COX inhibitors. The …

Metabolites of arachidonic acid participate in normal growth responses and in aberrant
cellular growth and proliferation, including carcinogenesis. The key step in the conversion of …

Cyclooxygenase (COX) enzyme-dependent arachidonic acid metabolites occupy key
positions in important physiologic processes such as immunity, reproduction, and vascular …