The two isoforms cyclooxygenase-1 and-2 catalyze the initial step in the formation of
prostaglandins in a variety of pathophysiological processes. More recently their role in …

COX-2 is an isoenzyme of cyclooxygenase that is increased in response to growth factors,
cytokines, and other mitogenic stimuli. Upregulation of COX-2 gene expression and …

Aspirin has been used to control pain and inflammation for over a century. Epidemiological
studies first associated a decreased incidence of colorectal cancer with the long-term use of …

Chronic inflammation is a tissue-specific process implicated in several diseases of an aging
population, including cancer, cardiovascular disease, and arthritis. Cyclooxygenase-2 (COX …

Chemopreventive strategies for colorectal cancer (CRC) have been extensively studied to
prevent the recurrence of adenomas and/or delay their development in the gastrointestinal …

Familial adenomatous polyposis (FAP) represents the setting for less than 1% of colorectal
cancers, yet has provided invaluable information regarding the molecular evolution of this …

Despite recent improvements in chemotherapy and radiation therapy in cancer management
with the addition of biological agents, novel treatment approaches are needed to further …

The involvement of prostaglandins (PGs) and other eicosanoids in the development of
human cancer has been known for over two decades. Importantly, an increase in PG …

Non-steroidal anti-inflammatory drugs (NSAIDs) have as their common mechanism the
inhibition of cyclooxygenase (COX) enzymes, of which two isoforms (COX-1 and COX-2) …

There is compelling evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) and
cyclooxygenase-2 selective inhibitors have antineoplastic activity, but toxicity from …