Colorectal cancer is a major cause of mortality and whilst up to 80% of sporadic colorectal
tumours are considered preventable, trends toward increasing obesity suggest the potential …

Abstract Cyclooxygenase-2 (COX-2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers …

Nm 04 April.indd Page 1 © 1998 Nature Publishing Group http://www.nature.com/naturemedicine
NEWS&: VIE …

Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to have a
property to inhibit tumor development in some cancers while it shows various side effects …

The cyclo-oxygenase (COX) metabolic pathway and prostaglandin (PG) production appear
to play a causal role in the promotion and progression of human cancers. COX-1 and COX-2 …

This chapter briefly summarizes the current knowledge about the role of nonsteroidal anti-
inflammatory drugs (NSAIDs), specially focusing on those selective for cyclooxygenase …

Carcinoma of the colon or rectum represents one of the most common malignancies
worldwide with a higher prevalence in industrialized regions. Epidemiologic studies of …

Cyclooxygenase-2 (COX-2) is an inducible enzyme which triggers the biosynthesis of
prostaglandins. COX-2 is activated in response to inflammatory stimuli and is one of the …

The regular intake of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has
been associated with decreased incidence of certain types of cancer particularly those with …

Research into COX-2 inhibitors is expanding rapidly out of the animal testing phase, with
results so far suggesting that this novel class of compounds may be useful in prevention as …