Cystic fibrosis (CF) is a genetic disease mainly manifested in the respiratory tract.
Pseudomonas aeruginosa (P. aeruginosa) is the most common pathogen identified in …

We propose novel oil-in-water nanoemulsions (O/W NEs) including PEGylated surfactants
and chitosan, showing good biocompatibility and optimization for nasal administration of …

Mucosal surfaces pose a challenging environment for efficient drug delivery. Various
delivery strategies such as nanoparticles have been employed so far; yet, still yielding …

Lysozyme dextran nanogels (NG) have great potential in vitro as a drug delivery platform,
combining simple chemistry with rapid uptake and cargo release in target cells with “stealth” …

Repurposing of the anthelminthic drug niclosamide was proposed as an effective treatment
for inflammatory airway diseases such as asthma, cystic fibrosis, and chronic obstructive …

Despite extensive research on corticosteroids for treating asthma, their short residence time
in the lungs has limited their therapeutic effects in vivo. Nanoparticles have been widely …

Mucus is a highly hydrated viscoelastic gel present on various moist surfaces in our body
including the eyes, nasal cavity, mouth, gastrointestinal, respiratory and reproductive tracts …

Nasal vaccination is considered a potent and practical immunization route for the induction
of effective immunity to infectious diseases. Successful nasal vaccines require efficient …

Mucus gel constitutes of heavily cross-linked mucin fibers forming a viscoelastic, dense
porous network that coats all the exposed epithelia not covered with the skin. The layer …

A high dose of amoxicillin is recommended as the first-line therapy for acute bacterial
rhinosinusitis (ABR). However, oral administration of amoxicillin is connected to many …