Ceramides are an emerging class of anti-inflammatory lipids, and nanoscale ceramide-
delivery systems are potential therapeutic strategies for inflammatory diseases. This study …

Hypothesis: Alginate is widely used in biomedical applications due to its high
biocompatibility as well as structural and mechanical similarities to human tissue. Further …

Several studies have stated that mucus is a critical hurdle for drug delivery to the mucosal
tissues. As a result, Polymeric nanoparticles that can overcome mucus barriers are gaining …

Airway mucus is a hydrogel with unique biophysical properties due to its primary water
composition and a small proportion of large anionic glycoproteins or mucins. The …

The conducting airways of the human lungs are lined by mucus, which lubricates the lung
epithelium and provides a first-line protection against airborne threats. As a novel approach …

Berberine (Ber) is an isoquinoline alkaloid that has shown therapeutic potential in mice with
chronic obstructive pulmonary disease (COPD). However, the therapeutic efficiency of Ber is …

Background Inhaled corticosteroids provide unique systems for local treatment of asthma or
chronic obstructive pulmonary disease. However, the use of poorly soluble drugs for …

Mucus is a complex viscoelastic gel and acts as a barrier covering much of the soft tissue in
the human body. High vascularization and accessibility have motivated drug delivery to …

Acute lung injury (ALI) remains one of the most common complications of sepsis. Although
many potential effective pharmacologic and ventilatory treatment strategies have been …

Despite the wide interest raised by lung administration of nanoparticles (NPs) for the
treatment of various diseases, little information is available on their effect toward the airway …