Bacterial DNA and synthetic oligonucleotides containing unmethylated CpG dinucleotides
(CpG DNA) activate the vertebrate immune system and promote Th1-like immune …

Bacterial and synthetic DNA containing unmethylated CpG dinucleotides activate the innate
immune system and promote Th1-like immune responses. Recently, a receptor, TLR9, has …

Several types of immune cells possess pattern recognition receptors (PRR) that can
distinguish prokaryotic DNA from vertebrate DNA by detecting unmethylated CpG …

Certain vertebrate immune cells have evolved receptors that detect the presence of
pathogen DNA based on its content of unmethylated CpG dinucleotides in particular base …

Bacterial DNA and oligonucleotides containing unmethylated CpG dinucleotides (CpG DNA)
can stimulate immune responses and have potential for use as novel agents to enhance …

The observation that oligodeoxynucleotides containing CpG dinucleotides (CpG DNA)
exhibit several immunological effects has led to their use as therapeutic agents and …

The genomes of bacterial and viral DNA contain a much higher frequency of unmethylated
CpG dinucleotides than those of vertebrates. This difference in genome structure allows the …

Synthetic oligodeoxyribonucleotides containing CpG-dinucleotides (CpG DNA) in specific
sequence contexts activate the vertebrate immune system. We have examined the effect of …

Bacterial and synthetic DNAs, containing CpG dinucleotides in specific sequence contexts,
activate the vertebrate immune system. Unlike phosphorothioate (PS) CpG DNAs …

Aside from its function as the “blueprint of life” that encodes genetic information, DNA can
have direct immune activities. The immune system has evolved a defense mechanism that is …