Five variants of human β-defensins (HBDs) were expressed in Escherichia coli using two
vector systems (pET28a (+) and pQE30) with inducible expression by IPTG. The last vector …

Human beta-defensins (hBDs) are crucial peptides for the innate immune response and are
thus prime candidates as therapeutic agents directed against infective diseases. Based on …

ABSTRACT Human β-defensins 2 and 3 (HBD-2 and HBD-3) are inducible peptides present
at sites of infection in the oral cavity. A few studies have reported broad-spectrum …

Background Human β-defensin-3 (HBD 3) is an epithelial peptide that has been
demonstrated to have a salt-insensitive broad spectrum of potent antimicrobial activity …

Human β-defensins form a group of cysteine-rich antimicrobial peptides which have been
found in epithelial tissue and, more recently, in the male genital tract. They play a role in the …

Abstract Background Human β-defensin-4 (hBD-4), a new member of the β-defensin family,
was discovered by an analysis of the genomic sequence. The objective of this study was to …

We successfully produced two human β-defensins (hBD-1 and hBD-2) in bacteria as
functional peptides and tested their antibacterial activities against Salmonella enterica …

Human β-defensin-3 (HBD3), an endogenous antimicrobial peptide, has strong broad-
spectrum antimicrobial activity. This study aimed to obtain recombinant HBD3 (rHBD3) and …

The antibacterial activities of synthetic human β-defensin analogs, constrained by a single
disulfide bridge and in the reduced form, have been investigated. The peptides span the …

The growing public health problem of infections caused by multiresistant Gram-positive
bacteria, in particularStaphylococcus aureus, prompted us to screen human epithelia for …