Abstract β-Defensins are cationic peptides produced by epithelial cells that have been
proposed to be an important component of immune function at mucosal surfaces. Similarities …

This work reports the first successful recombinant expression and purification of human beta-
defensin 5 (HBD5) and human beta-defensin 6 (HBD6) in Escherichia coli. HBD5 and HBD6 …

Defensins are a family of secreted antimicrobial peptides proposed to directly interfere with
bacterial membranes. Here we show a functional analysis of the novel β‐defensin …

Naturally occurring cationic antimicrobial peptides (CAPs) are an essential component of the
innate immune system of multicellular organisms. At concentrations generally higher than …

Human β-defensin-2 (hBD-2), a novel antimicrobial peptide, was originally isolated from
human skin. We found that synthetic hBD-2 has high bactericidal activity againstEscherichia …

Natural defences in the human body function to protect us from numerous environmental
toxins and exposure to potential harmful biological agents. An important frontline defence is …

One component of host defense at mucosal surfaces is epithelium-derived peptides with
antimicrobial activity called defensins. We describe in this report the isolation and …

Microbial resistance against clinical used antibiotics is on the rise. Accordingly, there is a
high demand for new innovative antimicrobial strategies. The host-defense peptide human …

Human beta-defensins (hBDs) are crucial factors of intrinsic immunity that function in the
immunologic response to a variety of invading enveloped viruses, bacteria, and fungi. hBDs …

ABSTRACT β-Defensins are cationic peptides with broad-spectrum antimicrobial activity that
may play a role in mucosal defenses of several organs. They have been isolated in several …