Studies suggest that activation of phosphoinositide 3‐kinase‐Akt may protect against
neuronal cell death in Alzheimer's disease (AD). Here, however, we provide evidence of …

The modification of proteins by reversible phosphorylation is a key mechanism in the
regulation of various physiological functions. Abnormal protein kinase or phosphatase …

The phosphatidylinositol 3 kinase (PI3K)‐Akt/PKB pathway protects neurons from apoptosis
caused by diverse stress stimuli. However, its protective role against the amyloid beta …

Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity
and mortality in aged population. Several transcription molecules, pathways, and molecular …

Protein phosphorylation of serine, threonine, and tyrosine residues is one of the most
prevalent post-translational modifications fundamental in mediating diverse cellular …

Significant attention has been drawn to the potential role of defective PI3-kinase-Akt (PKB)
signalling in Parkinson's disease (PD) neurodegeneration and to the possibility that …

Given the critical role of mitogen-activated protein kinase (MAPK) pathways in regulating
cellular processes that are affected in Alzheimer's disease (AD), the importance of MAPKs in …

Aims: Synaptic deficits are known to underlie the cognitive dysfunction seen in Alzheimer's
disease (AD). Generation of reactive oxygen species (ROS) by β-amyloid has also been …

The abnormal hyperphosphorylation of tau in Alzheimer's disease (AD) has been proposed
to involve the extracellular-signal-regulated protein kinase (ERK) of the mitogen-activated …

Abstract Characterization of the earliest neuropathologic features of Alzheimer disease (AD)
indicates that synaptic degeneration accompanied by tau hyperphosphorylation and …