Structural and functional features of central nervous system lymphatic vessels

A Louveau, I Smirnov, TJ Keyes, JD Eccles… - Nature, 2015 - nature.com
One of the characteristics of the central nervous system is the lack of a classical lymphatic
drainage system. Although it is now accepted that the central nervous system undergoes …

A (delayed) history of the brain lymphatic system

S Sandrone, D Moreno-Zambrano, J Kipnis… - Nature medicine, 2019 - nature.com
A (delayed) history of the brain lymphatic system | Nature Medicine Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …

Lymphangiogenesis in development and human disease

K Alitalo, T Tammela, TV Petrova - Nature, 2005 - nature.com
The lymphatic vasculature forms a vessel network that drains interstitial fluid from tissues
and returns it to the blood. Lymphatic vessels are also an essential part of the body's …

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

JH Ahn, H Cho, JH Kim, SH Kim, JS Ham, I Park… - Nature, 2019 - nature.com
Recent work has shown that meningeal lymphatic vessels (mLVs), mainly in the dorsal part
of the skull, are involved in the clearance of cerebrospinal fluid (CSF), but the precise route …

Lymphatics in neurological disorders: a neuro-lympho-vascular component of multiple sclerosis and Alzheimer's disease?

A Louveau, S Da Mesquita, J Kipnis - Neuron, 2016 - cell.com
Lymphatic vasculature drains interstitial fluids, which contain the tissue's waste products,
and ensures immune surveillance of the tissues, allowing immune cell recirculation. Until …

The movers and shapers in immune privilege of the CNS

B Engelhardt, P Vajkoczy, RO Weller - Nature immunology, 2017 - nature.com
Discoveries leading to an improved understanding of immune surveillance of the central
nervous system (CNS) have repeatedly provoked dismissal of the existence of immune …

Neuroinflammation creates an immune regulatory niche at the meningeal lymphatic vasculature near the cribriform plate

M Hsu, C Laaker, A Madrid, M Herbath, YH Choi… - Nature …, 2022 - nature.com
Meningeal lymphatics near the cribriform plate undergo lymphangiogenesis during
neuroinflammation to drain excess fluid. Here, we hypothesized that lymphangiogenic …

Brain borders at the central stage of neuroimmunology

J Rustenhoven, J Kipnis - Nature, 2022 - nature.com
The concept of immune privilege suggests that the central nervous system is isolated from
the immune system. However, recent studies have highlighted the borders of the central …

Biological functions of lymphatic vessels

TV Petrova, GY Koh - Science, 2020 - science.org
BACKGROUND Blood and lymphatic vessel networks form two arms of the vertebrate
cardiovascular system that play complementary roles in body homeostasis maintenance and …

Afferent and efferent immunological pathways of the brain. Anatomy, function and failure

RO Carare, CA Hawkes, RO Weller - Brain, behavior, and immunity, 2014 - Elsevier
Immunological privilege appears to be a product of unique lymphatic drainage systems for
the brain and receptor-mediated entry of inflammatory cells through the blood–brain barrier …