The kidney contains many mitochondria that generate ATP to provide energy for cellular
processes. Oxidative stress injury can be caused by impaired mitochondria with excessive …

With the increasing patients and limited therapeutic options, diabetic nephropathy (DN) is a
long-term complication of diabetic mellitus. The precise mechanism of DN is not yet fully …

Diabetic tubulopathy (DT) is a recently recognized key pathology of diabetic kidney disease
(DKD). The mitochondria-centric view of DT is emerging as a vital pathological factor in …

Chronic kidney disease (CKD) is a leading public health problem with high morbidity and
mortality. However, the therapies remain limited. Traditional Chinese medicine (TCM) has …

Defective antioxidant system as well as mitochondrial dysfunction contributes to the
pathogenesis and progression of diabetic kidney disease (DKD). Nuclear factor erythroid 2 …

With the advances in biomedical technologies, natural products have attracted substantial
public attention in the area of drug discovery. Flavonoids are a class of active natural …

Diabetic kidney disease (DKD) is the predominant complication of diabetes mellitus (DM)
and the leading cause of chronic kidney disease and end-stage renal disease worldwide …

The aim of this study was to investigate the effect and possible mechanism of Astragaloside
IV (AS-IV) on retarding the progression of diabetic nephropathy (DN) in a type 2 diabetic …

The kidneys are highly metabolic organs that produce vast quantities of adenosine
triphosphate via oxidative phosphorylation and, as such, contain many mitochondria …

Mitochondrial oxidative stress is a significant contributor to the pathogenesis of diabetic
kidney disease (DKD). We previously showed that mitochondrial oxidative stress in the …