Promising therapeutic mechanism for Chinese herbal medicine in ameliorating renal fibrosis in diabetic nephropathy

S Wang, S Qin, B Cai, J Zhan, Q Chen - Frontiers in Endocrinology, 2023 - frontiersin.org
Diabetic nephropathy (DN) is one of the most serious chronic microvascular abnormalities of
diabetes mellitus and the major cause of uremia. Accumulating evidence has confirmed that …

Resveratrol protects against hyperglycemia-induced oxidative damage to mitochondria by activating SIRT1 in rat mesangial cells

Y Xu, L Nie, YG Yin, JL Tang, JY Zhou, DD Li… - Toxicology and applied …, 2012 - Elsevier
Oxidative stress and mitochondrial dysfunction are involved in the pathogenesis of diabetic
nephropathy (DN). Resveratrol has potent protective effects on diabetes and diabetic …

Chinese medicine for treating diabetic nephropathy

B Wang, L Lin, Q Ni, C Su - Chinese journal of integrative medicine, 2011 - Springer
Diabetic nephropathy is one of the main causes of renal end-stage disease. The
pathogenesis of diabetic nephropathy is complex. The current treatment is only for a …

Natural compounds targeting mitochondrial dysfunction: emerging therapeutics for target organ damage in hypertension

X Liao, Y Han, Y He, J Liu, Y Wang - Frontiers in Pharmacology, 2023 - frontiersin.org
Hypertension generally causes target organ damage (TOD) in the heart, brain, kidney, and
blood vessels. This can result in atherosclerosis, plaque formation, cardiovascular and …

[HTML][HTML] The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

LI Xiao, X Xu, F Zhang, M Wang, Y Xu, D Tang, J Wang… - Redox biology, 2017 - Elsevier
Mitochondria play a crucial role in tubular injury in diabetic kidney disease (DKD). MitoQ is a
mitochondria-targeted antioxidant that exerts protective effects in diabetic mice, but the …

Mitochondrial activity contributes to impaired renal metabolic homeostasis and renal pathology in STZ-induced diabetic mice

M Wu, S Li, X Yu, W Chen, H Ma… - American Journal …, 2019 - journals.physiology.org
Diabetic nephropathy (DN) has become the main cause of end-stage renal disease
worldwide, but the efficacy of current therapeutic strategies on DN remains unsatisfactory …

[HTML][HTML] Natural Products as Pharmacological Modulators of Mitochondrial Dysfunctions for the Treatment of Diabetes and Its Complications: An update since 2010

QR Lin, LQ Jia, M Lei, D Gao, N Zhang, L Sha… - Pharmacological …, 2024 - Elsevier
Diabetes, characterized as a well-known chronic metabolic syndrome, with its associated
complications pose a substantial and escalating health and healthcare challenge on a …

[HTML][HTML] Artemether improves type 1 diabetic kidney disease by regulating mitochondrial function

Y Wang, P Han, M Wang, W Weng, H Zhan… - American Journal of …, 2019 - ncbi.nlm.nih.gov
Many patients with type 1 diabetes mellitus suffer from progressive diabetic kidney disease
(DKD). The progression of DKD is largely attributed to mitochondrial dysfunction, with key …

Indispensable role of mitochondria in maintaining the therapeutic potential of curcumin in acute kidney injury

L Li, S Liu, Y Zhou, M Zhao, Y Wang… - Journal of Cellular …, 2021 - Wiley Online Library
Acute kidney injury (AKI) is a serious disease for which effective therapeutic agents are
required. The capacity of curcumin (CUR) to resolve renal inflammation/oxidative stress and …

Shaping up mitochondria in diabetic nephropathy

K Mise, DL Galvan, FR Danesh - Kidney360, 2020 - journals.lww.com
Mitochondrial medicine has experienced significant progress in recent years and is
expected to grow significantly in the near future, yielding many opportunities to translate …