BaoShenTongLuo formula protects against podocyte injury by regulating AMPK-mediated mitochondrial biogenesis in diabetic kidney disease

Y Guo, M Wang, Y Liu, Y Pang, L Tian, J Zhao, M Liu… - Chinese Medicine, 2023 - Springer
Background Mitochondrial dysfunction is considered to be an important contributor in
podocyte injury under diabetic conditions. The BaoShenTongLuo (BSTL) formula has been …

Mechanisms of herbal nephroprotection in diabetes mellitus

D Dragoș, MM Manea, D Timofte… - Journal of Diabetes …, 2020 - Wiley Online Library
Diabetic nephropathy (DN) is a leading cause of kidney morbidity. Despite the multilayered
complexity of the mechanisms involved in the pathogenesis of DN, the conventional …

Diabetes cardiomyopathy: targeted regulation of mitochondrial dysfunction and therapeutic potential of plant secondary metabolites

X Pan, E Hao, F Zhang, W Wei, Z Du, G Yan… - Frontiers in …, 2024 - frontiersin.org
Diabetic cardiomyopathy (DCM) is a specific heart condition in diabetic patients, which is a
major cause of heart failure and significantly affects quality of life. DCM is manifested as …

Chinese herbal medicine in ameliorating diabetic kidney disease via activating autophagy

Y Wang, H Zhao, Q Wang, X Zhou, X Lu… - Journal of diabetes …, 2019 - Wiley Online Library
Diabetic kidney disease (DKD), a leading cause of end‐stage renal disease (ESRD), has
become a serious public health problem worldwide and lacks effective therapies due to its …

Astragaloside IV alleviates 1-deoxysphinganine-induced mitochondrial dysfunction during the progression of chronic kidney disease through p62-Nrf2 antioxidant …

T Gui, Q Chen, J Li, K Lu, C Li, B Xu, Y Chen… - Frontiers in …, 2023 - frontiersin.org
Introduction: Chronic kidney disease (CKD) can lead to significant elevation of 1-
deoxysphingolipids (1-deoxySL). The increase of 1-deoxySL in turn can result in …

Melatonin attenuates renal fibrosis in diabetic mice by activating the AMPK/PGC1α signaling pathway and rescuing mitochondrial function

J Li, N Li, S Yan, Y Lu, X Miao… - Molecular medicine …, 2019 - spandidos-publications.com
Mitochondrial homeostasis is a highly regulated process that serves a critical role in the
maintenance of renal structure and function. The growing interest in the field of …

Protective effects of purple rice husk against diabetic nephropathy by modulating PGC-1α/SIRT3/SOD2 signaling and maintaining mitochondrial redox equilibrium in …

O Wongmekiat, N Lailerd, A Kobroob… - Biomolecules, 2021 - mdpi.com
Diabetic nephropathy (DN) is the primary cause of end-stage renal disease worldwide.
Oxidative stress and mitochondrial dysfunction are central to its pathogenesis. Rice husk …

Berberine reduces lipid accumulation by promoting fatty acid oxidation in renal tubular epithelial cells of the diabetic kidney

Q Rong, B Han, Y Li, H Yin, J Li, Y Hou - Frontiers in pharmacology, 2022 - frontiersin.org
Abnormal lipid metabolism in renal tubular epithelial cells contributes to renal lipid
accumulation and disturbed mitochondrial bioenergetics which are important in diabetic …

Mechanistic insight of diabetic nephropathy and its pharmacotherapeutic targets: an update

N Bhattacharjee, S Barma, N Konwar… - European journal of …, 2016 - Elsevier
Diabetic nephropathy (DN), a chronic complication of diabetes, is charecterized by
glomerular hypertrophy, proteinuria, decreased glomerular filtration, and renal fibrosis …

Mitochondrial contribution to inflammation in diabetic kidney disease

A Mitrofanova, AM Fontanella, GW Burke, S Merscher… - Cells, 2022 - mdpi.com
Diabetes is the leading cause of chronic kidney disease worldwide. Despite the burden, the
factors contributing to the development and progression of diabetic kidney disease (DKD) …