Bioactive phytochemicals that regulate the cellular processes involved in diabetic nephropathy

A Parveen, M Jin, SY Kim - Phytomedicine, 2018 - Elsevier
Background Owing to the multiple causative factors, the current advances in medication for
diabetic nephropathy (DN) do not appear to have improved therapies for patients …

Mitochondrial dysfunction in individuals with diabetic kidney disease: a systematic review

N Flemming, L Pernoud, J Forbes, L Gallo - Cells, 2022 - mdpi.com
Mitochondrial dysfunction is implicated in the pathogenesis of diabetic kidney disease
(DKD). Compared to the vast body of evidence from preclinical in vitro and in vivo studies …

[HTML][HTML] Broadening horizons: the contribution of mitochondria-associated endoplasmic reticulum membrane (MAM) dysfunction in diabetic kidney disease

Y Liu, Y Qiao, S Pan, J Chen, Z Mao… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Diabetic kidney disease (DKD) is a global health issue that presents a complex
pathogenesis and limited treatment options. To provide guidance for precise therapies, it is …

[PDF][PDF] Oxidative stress mediated mitochondrial damage plays roles in pathogenesis of diabetic nephropathy rat.

X Chen, M Fang - European Review for Medical & …, 2018 - europeanreview.org
OBJECTIVE: Diabetic nephropathy (DN) is considered as a complication of diabetes and
accounts for about 40%. Reactive oxygen species (ROS) level continues to increase in DN …

Diosgenin targets CaMKK2 to alleviate type II diabetic nephropathy through improving autophagy, mitophagy and mitochondrial dynamics

Y Zhong, R Jin, R Luo, J Liu, L Ren, Y Zhang, Z Shan… - Nutrients, 2023 - mdpi.com
Diabetic nephropathy (DN) is a worldwide health problem with increasing incidence.
Diosgenin (DIO) is a natural active ingredient extracted from Chinese yams (Rhizoma …

NADH/NAD+ Redox Imbalance and Diabetic Kidney Disease

LJ Yan - Biomolecules, 2021 - mdpi.com
Diabetic kidney disease (DKD) is a common and severe complication of diabetes mellitus. If
left untreated, DKD can advance to end stage renal disease that requires either dialysis or …

Astragalin ameliorates renal injury in diabetic mice by modulating mitochondrial quality control via AMPK-dependent PGC1α pathway

M Sun, H Ye, C Zheng, Z Jin, Y Yuan… - Acta pharmacologica …, 2023 - nature.com
Diabetic kidney disease (DKD) is a common microvascular complication of diabetes
mellitus, and oxidative stress and mitochondrial dysfunction play an important role in this …

[HTML][HTML] Hyperoside alleviates adriamycin-induced podocyte injury via inhibiting mitochondrial fission

Z Chen, X An, X Liu, J Qi, D Ding, M Zhao, S Duan… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Podocyte injury underlies many forms of glomerular diseases. Our previous study showed
that hyperoside, a naturally occurring flavonoid, could decrease albuminuria at the early …

Therapeutic approach of flavonoid in ameliorating diabetic cardiomyopathy by targeting mitochondrial-induced oxidative stress

S Sapian, IS Taib, J Latip, H Katas, KY Chin… - International Journal of …, 2021 - mdpi.com
Diabetes cardiomyopathy is one of the key factors of mortality among diabetic patients
around the globe. One of the prior contributors to the progression of diabetic cardiomyopathy …

Glucose-and non-glucose-induced mitochondrial dysfunction in diabetic kidney disease

M Ito, MZ Gurumani, S Merscher, A Fornoni - Biomolecules, 2022 - mdpi.com
Mitochondrial dysfunction plays an important role in the pathogenesis and progression of
diabetic kidney disease (DKD). In this review, we will discuss mitochondrial dysfunction …