Astragalin ameliorates renal injury in diabetic mice by modulating mitochondrial quality control via AMPK-dependent PGC1α pathway

M Sun, H Ye, C Zheng, Z Jin, Y Yuan… - Acta pharmacologica …, 2023 - nature.com
Diabetic kidney disease (DKD) is a common microvascular complication of diabetes
mellitus, and oxidative stress and mitochondrial dysfunction play an important role in this …

Nimbidiol protects from renal injury by alleviating redox imbalance in diabetic mice

SK Juin, S Pushpakumar, U Sen - Frontiers in Pharmacology, 2024 - frontiersin.org
Introduction Chronic hyperglycemia-induced oxidative stress plays a crucial role in the
development of diabetic nephropathy (DN). Moreover, adverse extracellular matrix (ECM) …

[HTML][HTML] The effect of Chinese medicinal formulas on biomarkers of oxidative stress in STZ-induced diabetic kidney disease rats: A meta-analysis and systematic …

Q Zhou, C Han, Y Wang, S Fu, Y Chen… - Frontiers in Medicine, 2022 - frontiersin.org
Background Diabetic kidney disease (DKD), defined broadly as persistent proteinuria with
low estimated glomerular filtration rate in patients with diabetes, is a main cause of end …

[HTML][HTML] Therapeutic approach of flavonoid in ameliorating diabetic cardiomyopathy by targeting mitochondrial-induced oxidative stress

S Sapian, IS Taib, J Latip, H Katas, KY Chin… - International Journal of …, 2021 - mdpi.com
Diabetes cardiomyopathy is one of the key factors of mortality among diabetic patients
around the globe. One of the prior contributors to the progression of diabetic cardiomyopathy …

[PDF][PDF] Mitochondria-targeted drugs for diabetic kidney disease

A Mima - Heliyon, 2022 - cell.com
Diabetic kidney disease (DKD) is one of the most frequent causes of chronic kidney disease
(CKD) in the United States. Chronic hyperglycemic conditions are thought to be the primary …

Protective role of green tea on diabetic nephropathy—A review

M Mohabbulla Mohib, SM Fazla Rabby, TZ Paran… - Cogent …, 2016 - Taylor & Francis
Nowadays, diabetes and diabetes-mediated dysfunctions are overwhelming at every nook
and corner of the world which has been a sober concern to the current health care …

[HTML][HTML] Glucose-and non-glucose-induced mitochondrial dysfunction in diabetic kidney disease

M Ito, MZ Gurumani, S Merscher, A Fornoni - Biomolecules, 2022 - mdpi.com
Mitochondrial dysfunction plays an important role in the pathogenesis and progression of
diabetic kidney disease (DKD). In this review, we will discuss mitochondrial dysfunction …

Mitochondrial dysfunction and oxidative stress: Role in chronic kidney disease

A Srivastava, B Tomar, D Sharma, SK Rath - Life Sciences, 2023 - Elsevier
Chronic kidney disease (CKD) is associated with a variety of distinct disease processes that
permanently change the function and structure of the kidney across months or years. CKD is …

[HTML][HTML] Metformin attenuates diabetic renal injury via the AMPK‑autophagy axis

T Sun, J Liu, C Xie, J Yang… - Experimental and …, 2021 - spandidos-publications.com
Diabetic nephropathy (DN) is a clinical condition characterized by kidney damage that is
observed in patients with diabetes. DN is the main cause of end‑stage renal disease …

Sitagliptin Ameliorates Renal Tubular Injury in Diabetic Kidney Disease via STAT3-Dependent Mitochondrial Homeostasis Through SDF-1α/CXCR4 Pathway

Q Zhang, L He, F Liu, J Guan, Y Dong, Y Fei, J Wen… - 2019 - papers.ssrn.com
Background: Mitochondrial abnormalities play critical roles in diabetic tubular injury
progression. Dipeptidyl peptidase-4 (DPP4) inhibitors are widely used antihyperglycaemic …