Maintaining a highly acidic lysosomal pH is central to cellular physiology. Here, we use
functional proteomics, single-particle cryo-EM, electrophysiology, and in vivo imaging to …

Whereas we have a profound understanding about the function and biogenesis of the
protein constituents in the lumen of the lysosomal compartment, much less is known about …

The lysosomal membrane proteins LAMP-1 and LAMP-2 are estimated to contribute to about
50% of all proteins of the lysosome membrane. Surprisingly, mice deficient in either LAMP-1 …

It has recently become clear that lysosomes have more complex functions than simply being
the end-point on a degradative pathway. Similarly, it is now emerging that there are …

The acidic environment within lysosomes is maintained within a narrow pH range (pH 4.5-
5.0) optimal for digesting autophagic cargo macromolecules so that the resulting building …

Lysosomes are the major organelles that carry out degradation functions. They integrate and
digest materials compartmentalized by endocytosis, phagocytosis or autophagy. In addition …

The present nomenclature of the splice variants of the lysosome‐associated membrane
protein type 2 (LAMP‐2) is confusing. The LAMP‐2a isoform is uniformly named in human …

Lysosomal membranes contain two highly glycosylated proteins, designated LAMP-1 and
LAMP-2, as major components. LAMP-1 and LAMP-2 are structurally related. To investigate …

Despite widespread distribution of LAMP1 and the heterogeneous nature of LAMP1-labeled
compartments, LAMP1 is routinely used as a lysosomal marker, and LAMP1-positive …

Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …