Biochemical and genetic analysis of apoptosis has determined that intracellular proteases
are key effectors of cell death pathways. In particular, early studies have pointed to the …

Caspases play an essential role during apoptotic cell death. These enzymes define a new
class of cysteine proteases and comprise a multi-gene family with more than a dozen distinct …

Apoptosis, a morphologically defined form of physiological cell death, is implemented by a
death machinery whose executionary arm is a family of cysteine proteases called caspases …

The process of apoptosis, or programmed cell death, is fundamental during normal
development and homeostasis and aberrant apoptosis has been implicated in a number of …

Caspases are a family of cysteine aspartyl proteases mostly involved in the execution of
apoptotic cell death and in regulating inflammation. This article focuses primarily on the …

Much of the proteolysis that occurs during apoptosis is directed by caspases, a family of
related cysteinyl proteases. A relatively small number of cellular proteins are targeted by …

▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

The activation of the caspase family of proteases has been detected in numerous cell
systems and appears to function as a common pathway through which apoptotic …

Apoptosis or programmed cell death (PCD) is a genetically regulated, cellular suicide
mechanism that plays a crucial role in development and in the defense of homeostasis …

Proteases were, for a long time, mainly considered as protein degrading enzymes. However,
in the last decade this view has changed dramatically, and the focus is now on proteases as …