Objectives Obesity is a complex disease long established to be strongly influenced by diet,
yet it is still unclear why no specific diet can effectively control obesity development across …

Defined as chronic excessive accumulation of adiposity, obesity results from long-term
imbalance between energy intake and expenditure. The mechanisms behind how caloric …

Background Obesity is a serious disease with a complex etiology characterized by
overaccumulation of adiposity resulting in detrimental health outcomes. Given the liver's …

Levels of human obesity have increased over the past 20 years worldwide, primarily due to
changes in diet and activity levels. Although environmental changes are clearly responsible …

Obesity is routinely considered as a single disease state, which drives a “one-size-fits-all”
approach to treatment. We recently convened the first annual University of North Carolina …

Obesity has reached epidemic proportions and is recognised as a significant global health
problem. Increased food intake and decreased physical activity are traditionally to blame for …

Objective Obesity is a major risk factor for multiple diseases and is in part heritable, yet the
majority of causative genetic variants that drive excessive adiposity remain unknown. Here …

Objective Obesity is influenced by genetic and environmental factors. Despite the success of
human genome‐wide association studies, the specific genes that confer obesity remain …

Inter-individual variation in metabolic health and adiposity is driven by many factors. Diet
composition and genetic background and the interactions between these two factors affect …

The epidemic of obesity has been affecting individuals globally, with roughly 650 million
adults obese in 2016 (WHO, 2021). According to the Centers for Disease Control and …