Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci
IM Stylianou, R Korstanje, R Li, S Sheehan… - Mammalian …, 2006 - Springer
Obesity is a highly heritable and genetically complex trait with hundreds of potential loci
identified. An intercross of 513 F 2 progeny between the SM/J× NZB/BINJ inbred mouse …
identified. An intercross of 513 F 2 progeny between the SM/J× NZB/BINJ inbred mouse …
[HTML][HTML] High fat feeding unmasks variable insulin responses in male C57BL/6 mouse substrains
RL Hull, JR Willard, MD Struck, BM Barrow… - The Journal of …, 2017 - ncbi.nlm.nih.gov
Mouse models are widely used for elucidating mechanisms underlying type 2 diabetes.
Genetic background profoundly affects metabolic phenotype; therefore selecting the …
Genetic background profoundly affects metabolic phenotype; therefore selecting the …
Independent and Interactive Effects of Genetic Background and Sex on Tissue Metabolomes of Adipose, Skeletal Muscle, and Liver in Mice
Genetics play an important role in the development of metabolic diseases. However, the
relative influence of genetic variation on metabolism is not well defined, particularly in …
relative influence of genetic variation on metabolism is not well defined, particularly in …
Changes in gene expression foreshadow diet-induced obesity in genetically identical mice
RA Koza, L Nikonova, J Hogan, JS Rim… - PLoS …, 2006 - journals.plos.org
High phenotypic variation in diet-induced obesity in male C57BL/6J inbred mice suggests a
molecular model to investigate non-genetic mechanisms of obesity. Feeding mice a high-fat …
molecular model to investigate non-genetic mechanisms of obesity. Feeding mice a high-fat …
Genetic mapping of multiple traits identifies novel genes for adiposity, lipids, and insulin secretory capacity in outbred rats
Despite the successes of human genome-wide association studies, the causal genes
underlying most metabolic traits remain unclear. We used outbred heterogeneous stock …
underlying most metabolic traits remain unclear. We used outbred heterogeneous stock …
[HTML][HTML] Genomics of Metabolic and Tumor/Cancer Traits: High-fat diet negatively impacts both metabolic and behavioral health in outbred heterogeneous stock rats
AW Deal, O Seshie, A Lenzo, N Cooper… - Physiological …, 2020 - ncbi.nlm.nih.gov
Obesity is influenced by genetics and diet and has wide ranging comorbidities, including
anxiety and depressive disorders. Outbred heterogeneous stock (HS) rats are used for fine …
anxiety and depressive disorders. Outbred heterogeneous stock (HS) rats are used for fine …
Identification of behavioral and metabolic factors predicting adiposity sensitivity to both high fat and high carbohydrate diets in rats
PC Even, NA Nadkarni, C Chaumontet… - Frontiers in …, 2011 - frontiersin.org
Individuals exhibit a great variation in their body weight (BW) gain response to a high fat
diet. Identification of predictive factors would enable better directed intervention toward …
diet. Identification of predictive factors would enable better directed intervention toward …
Sex and species differences in the development of diet-induced obesity and metabolic disturbances in rodents
I Maric, JP Krieger, P van der Velden, S Börchers… - Frontiers in …, 2022 - frontiersin.org
Prevalence and health consequences of obesity differ between men and women. Yet, most
preclinical studies investigating the etiology of obesity have, to date, been conducted in …
preclinical studies investigating the etiology of obesity have, to date, been conducted in …
Improving metabolic health through precision dietetics in mice
WT Barrington, P Wulfridge, AE Wells, CM Rojas… - Genetics, 2018 - academic.oup.com
Barrington et al. examined the effect of four human diets (American, Mediterranean,
Japanese, and Maasai/ketogenic) on metabolic health across four mouse... The incidence of …
Japanese, and Maasai/ketogenic) on metabolic health across four mouse... The incidence of …
Quantitative trait loci for individual adipose depot weights in C57BL/6ByJ x 129P3/JF2 mice
DR Reed, AH McDaniel, X Li, MG Tordoff… - Mammalian …, 2006 - Springer
To understand how genotype influences fat patterning and obesity, we conducted an
autosomal genome scan using male and female F 2 hybrids between the C57BL/6ByJ and …
autosomal genome scan using male and female F 2 hybrids between the C57BL/6ByJ and …