Obesity is a highly heritable and genetically complex trait with hundreds of potential loci
identified. An intercross of 513 F 2 progeny between the SM/J× NZB/BINJ inbred mouse …

Mouse models are widely used for elucidating mechanisms underlying type 2 diabetes.
Genetic background profoundly affects metabolic phenotype; therefore selecting the …

Genetics play an important role in the development of metabolic diseases. However, the
relative influence of genetic variation on metabolism is not well defined, particularly in …

High phenotypic variation in diet-induced obesity in male C57BL/6J inbred mice suggests a
molecular model to investigate non-genetic mechanisms of obesity. Feeding mice a high-fat …

Despite the successes of human genome-wide association studies, the causal genes
underlying most metabolic traits remain unclear. We used outbred heterogeneous stock …

Obesity is influenced by genetics and diet and has wide ranging comorbidities, including
anxiety and depressive disorders. Outbred heterogeneous stock (HS) rats are used for fine …

Individuals exhibit a great variation in their body weight (BW) gain response to a high fat
diet. Identification of predictive factors would enable better directed intervention toward …

Prevalence and health consequences of obesity differ between men and women. Yet, most
preclinical studies investigating the etiology of obesity have, to date, been conducted in …

Barrington et al. examined the effect of four human diets (American, Mediterranean,
Japanese, and Maasai/ketogenic) on metabolic health across four mouse... The incidence of …

To understand how genotype influences fat patterning and obesity, we conducted an
autosomal genome scan using male and female F 2 hybrids between the C57BL/6ByJ and …