Improved solubility, dissolution rate, and oral bioavailability of main biflavonoids from Selaginella doederleinii extract by amorphous solid dispersion

B Chen, X Wang, Y Zhang, K Huang, H Liu, D Xu… - Drug Delivery, 2020 - Taylor & Francis
Abstract Amentoflavone, robustaflavone, 2 ″, 3 ″-dihydro-3′, 3‴-biapigenin, 3′, 3‴-
binaringenin, and delicaflavone are five major hydrophobic components in the total …

Proliposomes for oral delivery of total biflavonoids extract from Selaginella doederleinii: formulation development, optimization, and in vitro–in vivo characterization

B Chen, X Wang, D Lin, D Xu, S Li… - International Journal …, 2019 - Taylor & Francis
Purpose Amentoflavone, robustaflavone, 2'', 3''-dihydro-3', 3'''-biapigenin, 3', 3'''-binaringenin
and delicaflavone are five major active ingredients in the total biflavonoids extract from …

Simultaneous quantification of five biflavonoids in rat plasma by LC-ESI–MS/MS and its application to a comparatively pharmacokinetic study of Selaginella …

B Chen, X Wang, Y Zou, W Chen, G Wang… - … of Pharmaceutical and …, 2018 - Elsevier
Selaginella doederleinii Hieron is a widely used as folk Chinese medicine for treatment of
different cancers. Our previous investigations have confirmed that the total biflavonoids in …

Efficient, green extraction of two biflavonoids from Selaginella uncinata with deep eutectic solvents

G Qin, J Lei, S Li, Y Jiang, L Qiao, M Ren, Q Gao… - Microchemical …, 2022 - Elsevier
In this study, ultrasonic-assisted deep eutectic solvents (DESs-UAE) was applied for efficient
and environmentally friendly extraction of amentoflavone (AME) and robustaflavone (ROB) …

Preparative Isolation of six Anti‐Tumour Biflavonoids from Selaginella Doederleinii Hieron by High‐Speed Counter‐Current Chromatography

S Li, M Zhao, Y Li, Y Sui, H Yao… - Phytochemical …, 2014 - Wiley Online Library
Introduction Biflavonoids are the primary constituents of Selaginella doederleinii Hieron, to
which different bioactivities have been attributed, including anti‐cancer, anti‐inflammatory …

[HTML][HTML] Analysis of the Total Biflavonoids Extract from Selaginella doederleinii by HPLC-QTOF-MS and Its In Vitro and In Vivo Anticancer Effects

H Yao, B Chen, Y Zhang, H Ou, Y Li, S Li, P Shi, X Lin - Molecules, 2017 - mdpi.com
Selaginella doederleinii Hieron has been traditionally used as a folk antitumor herbal
medicine in China. In this paper, the phytochemical components of the total biflavonoids …

New cytotoxic biflavonoids from Selaginella delicatula

JJ Chen, CY Duh, JF Chen - Planta medica, 2005 - thieme-connect.com
Abstract Five new biflavonoids, robustaflavone 7, 4′, 4′′′-trimethyl ether,
robustaflavone 4′, 4′′′-dimethyl ether, 2, 3-dihydroamentoflavone 7, 4′, 7 …

Antitumor Activities of Ethyl Acetate Extracts from Selaginella doederleinii Hieron In Vitro and In Vivo and Its Possible Mechanism

J Wang, J Li, P Zhao, W Ma, X Feng… - Evidence‐Based …, 2015 - Wiley Online Library
The antitumor activities of ethyl acetate extracts from Selaginella doederleinii Hieron (SD
extracts) in vitro and in vivo and its possible mechanism were investigated. HPLC method …

[HTML][HTML] Pharmacokinetics, tissue distribution, and human serum albumin binding properties of delicaflavone, a novel anti-tumor candidate

B Chen, H Luo, W Chen, Q Huang, K Zheng… - Frontiers in …, 2021 - frontiersin.org
Delicaflavone (DF), a natural active ingredient from Selaginella doederleinii Hieron, has
been reported to have favorable anticancer effects and is thus considered a potential …

Cytotoxic Biflavonoids from Selaginella delicatula

LC Lin, YC Kuo, CJ Chou - Journal of Natural Products, 2000 - ACS Publications
Four new biflavonoids robustaflavone 4 '-methyl ether (1), robustaflavone 7, 4 '-dimethyl
ether (2), 2 '', 3 ''-dihydrorobustaflavone 7, 4 ',-dimethyl ether (3), and 2 '', 3 '' …