Simple in vitro models can predict pulmonary toxicity of silver nanoparticles

HM Braakhuis, C Giannakou, WJGM Peijnenburg… - …, 2016 - Taylor & Francis
To study the effects of nanomaterials after inhalation, a large number of in vitro lung models
have been reported in literature. Although the in vitro models contribute to the reduction of …

Identification of the appropriate dose metric for pulmonary inflammation of silver nanoparticles in an inhalation toxicity study

HM Braakhuis, FR Cassee, PHB Fokkens… - …, 2016 - Taylor & Francis
A number of studies have shown that induction of pulmonary toxicity by nanoparticles of the
same chemical composition depends on particle size, which is likely in part due to …

Particle size dependent deposition and pulmonary inflammation after short-term inhalation of silver nanoparticles

HM Braakhuis, I Gosens, P Krystek, JAF Boere… - Particle and fibre …, 2014 - Springer
Background Although silver nanoparticles are currently used in more than 400 consumer
products, it is not clear to what extent they induce adverse effects after inhalation during …

Toxicity of silver nanoparticles at the air‐liquid interface

AL Holder, LC Marr - BioMed research international, 2013 - Wiley Online Library
Silver nanoparticles are one of the most prevalent nanomaterials in consumer products.
Some of these products are likely to be aerosolized, making silver nanoparticles a high …

Lung models to evaluate silver nanoparticles' toxicity and their impact on human health

JG González-Vega, JC García-Ramos… - Nanomaterials, 2022 - mdpi.com
Nanomaterials (NMs) solve specific problems with remarkable results in several industrial
and scientific areas. Among NMs, silver nanoparticles (AgNPs) have been extensively …

Nanosilver induces minimal lung toxicity or inflammation in a subacute murine inhalation model

LV Stebounova, A Adamcakova-Dodd, JS Kim… - Particle and fibre …, 2011 - Springer
Background There is increasing interest in the environmental and health consequences of
silver nanoparticles as the use of this material becomes widespread. Although human …

Remote effects and biodistribution of pulmonary instilled silver nanoparticles in mice

Z Ferdous, S Al-Salam, P Yuvaraju, BH Ali, A Nemmar - NanoImpact, 2021 - Elsevier
Silver nanoparticles (AgNPs) are the most commonly used nanoparticles (NPs) owing to
their anti-microbial properties, and the pulmonary system provides a major portal of entry for …

In vitro toxicity assessment of silver nanoparticles in rat alveolar macrophages

C Carlson - 2006 - rave.ohiolink.edu
The present study was conducted to assess the toxicity of nanosized silver particles (Ag-
15nm, 30nm and 55nm) in rat alveolar macrophages. For toxicity evaluations, cellular …

Lobar evenness of deposition/retention in rat lungs of inhaled silver nanoparticles: an approach for reducing animal use while maximizing endpoints

JD Park, JK Kim, MS Jo, YH Kim, KS Jeon… - Particle and Fibre …, 2019 - Springer
Background Information on particle deposition, retention and clearance are important for the
evaluation of the risk of inhaled nanomaterials to human health. Recent revised OECD …

Mode of silver clearance following 28-day inhalation exposure to silver nanoparticles determined from lung burden assessment including post-exposure observation …

MS Jo, JK Kim, Y Kim, HP Kim, HS Kim, K Ahn… - Archives of …, 2020 - Springer
Recently revised OECD inhalation toxicity testing guidelines require measurements of lung
burden immediately after and for periods following exposure for nanomaterials. Lung burden …