Virus-Like Particles (VLPs) are nanostructures that share conformation and self-assembly
properties with viruses, but lack a viral genome and therefore the infectious capacity. In this …

Retinoic acid inducible gene I (RIG-I) is essential for directing and priming the host immune
response against many RNA viruses. A diverse small molecule library was used in a cell …

The SARS-CoV-2 pandemic has underscored the need for rapidly usable prophylactic and
antiviral treatments against emerging viruses. The targeted stimulation of antiviral innate …

The molecular interaction between viral RNA and the cytosolic sensor RIG-I represents the
initial trigger in the development of an effective immune response against infection with RNA …

Retinoic acid–inducible gene I (RIG-I) is essential for activating host cell innate immunity to
regulate the immune response against many RNA viruses. We previously identified that a …

Retinoic acid–inducible gene I–like receptors (RLRs) are cytosolic RNA sensors critical for
initiation of antiviral immunity. Activation of RLRs following RNA recognition leads to …

RIG-I is a key mediator of antiviral immunity, able to couple detection of infection by RNA
viruses to the induction of interferons. Natural RIG-I stimulatory RNAs have variously been …

Emerging and re-emerging viruses pose a significant public health challenge around the
world, among which RNA viruses are the cause of many major outbreaks of infectious …

As SARS-CoV-2 continues to cause morbidity and mortality around the world, there is an
urgent need for the development of effective medical countermeasures. Here, we assessed …

The RIG‐I pathway can be activated by RNA containing 5′ triphosphate, leading to type I
interferon release and immune activation. Hence, RIG‐I agonists have been used to induce …