The distribution of γ-glutamyl transpeptidase (γ-GTP), tyrosinase, and 5-S-cysteinyldopa (5-
S-CD) within melanoma cells has been studied in vitro as well as in vivo. Sodium periodate …

The roles of tyrosinase and γ‐glutamyl transpeptidase (γ‐GTP) in 5‐S‐cysteinyldopa (5‐S‐
CD) genesis in melanotic and amelanotic melanoma cells has been investigated in vitro and …

Gamma-glutamyl transpeptidase (GGT), an enzyme of the γ-glutamyl cycle, was
demonstrated in 3 of 6 cell lines derived from a single B16 murine melanoma. Its activity in …

The effect of dopa, cysteine, and glutathione on 5-S-cysteinyldopa (5-S-CD) genesis in
melanoma cells cultured in normal and tyrosine-and cysteine-free media has been studied …

The effect of DOPA and glutathione (GSH) on enzyme systems for 5-S-cysteinyl-DOPA
(5SCD) genesis in murine melanoma cells cultured in tyrosine-and cystine-free medium …

The aim of the present work was to estimate the effect of intracellular glutathione depletion
on melanogenesis in human melanoma cells. We determined tyrosine hydroxylation activity …

Glutathionedopa injected intravenously into mice is metabolized and excreted in the urine
as a compound with the fluorescence characteristics of cysteinyldopa. Glutathionedopa …

5-S-Glutathionyldopa is oxidized at incubation with tyrosinase and dopa producing a black
pigment. The reaction proceeds with the formation of two chromophores with absorption …

Cultured melanoma cells have been of great value in the study of pigment metabolism. IGR
1 human melanoma cells, established by Dr Christian Aubert, produce melanin in large …

The concentrations of dopa, cysteinyldopas, 5-S-glutathionyldopa, gamma-glutamyl-5-S-
cysteinyldopa and 5-S-cysteinylglycinedopa, were analysed in homogenates of cultured …