Musculoskeletal pain conditions, particularly those associated with temporomandibular
disorders (TMD) affect a large percentage of the population. Identifying mechanisms …

Temporomandibular joint disorder is a common chronic craniofacial pain condition, often
involving persistent, widespread craniofacial muscle pain. Although the etiology of chronic …

The involvement of TRPV1 and TRPA1 in mediating craniofacial muscle nociception and
mechanical hyperalgesia was investigated in male Sprague–Dawley rats. First, we …

Spontaneous pain and function-associated pain are prevalent symptoms of multiple acute
and chronic muscle pathologies. We established mouse models for evaluating spontaneous …

Formalin-evoked trigeminal pain behavior depends on TRPV4 calcium-permeable
channels, also on MEK-ERK signaling in trigeminal ganglion neurons. ABSTRACT …

Background Cultured sensory neurons are a common experimental model to elucidate the
molecular mechanisms of pain transduction typically involving activation of ATP-sensitive …

The NMDA and TRPV1 receptors that are expressed in sensory neurons have been
independently demonstrated to play important roles in peripheral pain mechanisms. In the …

The distribution and modulation of the P2X3 receptor was studied in trigeminal ganglion
neurons to provide insight into the role of ATP in craniofacial sensory mechanisms. Binding …

Temporomandibular joint disorder (TMJD) is known for its mastication-associated pain.
TMJD is medically relevant because of its prevalence, severity, chronicity, the therapy …

The exact mechanism of the masseter muscle pain recognized as a prominent symptom in
temporomandibular disorders remains unclear, although it is clinically known that excessive …