The mammalian target of rapamycin mTOR is a central element in an evolutionary
conserved signalling pathway that regulates cell growth, survival and proliferation …

The microbially derived antiproliferative agent rapamycin inhibits cell growth by interfering
with the signaling functions of the mammalian target of rapamycin (mTOR). In this study, we …

A variety of mechanisms confer hypersensitivity of tumor cells to the macrolide rapamycin,
the prototypic mTORC1 inhibitor. Several studies have shown that the status of the AKT …

The mammalian target of rapamycin (mTOR) is a downstream effector of the
phosphatidylinositol 3‐kinase (PI3K)/Akt (protein kinase B) signaling pathway, which …

Mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase that
regulates cell cycle progression, protein translation, metabolism, and cellular proliferation …

Stimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the
phosphoinositide-3-kinase/Akt/mTOR pathway causing pleiotropic cellular effects including …

The mammalian target of rapamycin (mTOR) coordinates cell growth with thegrowth factor
and nutrient/energy status of the cell. The phosphatidylinositol3-kinase-AKT pathway is …

Mechanistic target of rapamycin (mTOR) complex 1 is a central integrator of nutrient and
growth factor inputs that controls cell growth in eukaryotes. The second generation of mTOR …

It has been shown that mammalian target of rapamycin (mTOR) inhibitors activate Akt while
inhibiting mTOR signaling. However, the underlying mechanisms and the effect of the Akt …

The mammalian target of rapamycin (mTOR) regulates protein synthesis in addition to cell
growth and cell proliferation. Elucidation of the roles of the phosphatidylinositol 3-kinase …