Memory T cells can persist for extended periods in the absence of antigen, and long-term T
cell immunity is often seen after acute infections. Paradoxically, there have been …

A critical aim of vaccine‐related research is to identify the mechanisms by which memory T
cells are formed and maintained over long periods of time. In recent years, we have …

Virus-specific memory T cell populations demonstrate plasticity in antigen recognition and in
their ability to accommodate new memory T cell populations. The degeneracy of T cell …

Efficient maintenance of memory CD8 T cells is central to long-term protective immunity. IL-7–
and IL-15–driven homeostatic proliferation is essential for long-term memory CD8 T cell …

To design successful vaccines for chronic diseases, an understanding of memory CD8+ T
cell responses to persistent antigen restimulation is critical. However, most studies …

CD8 T cells are pivotal for the control of many intracellular pathogens, and besides their role
in immediate control of infections, CD8 T cells have the capacity to differentiate into long …

The main functions of memory T cells are to provide protection upon re‐exposure to a
pathogen and to prevent the re‐emergence of low‐grade persistent pathogens. Memory T …

Survival and intermittent proliferation of memory CD4+ and CD8+ T cells appear to be
controlled by different homeostatic mechanisms. In particular, contact with interleukin (IL)-15 …

How and when memory T cells form during an immune response are long-standing
questions. To better understand memory CD8 T cell development, a time course of gene …

The role of CD4 T cells in providing help to CD8 T cells in primary and secondary responses
to infection remains controversial. Using recombinant strains of virus and bacteria …